Virology articles within Nature Chemistry

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  • Article |

    An effective antiviral against the common cold could prevent exacerbations in asthma and chronic obstructive pulmonary disease, but the diversity and adaptability of the virus makes it a highly challenging target. Now, picomolar inhibitors of a human lipid transferase have been developed. Targeting this human lipid transferase could provide an effective and broad-spectrum approach to block viral replication in the host.

    • Aurélie Mousnier
    • , Andrew S. Bell
    •  & Edward W. Tate

  • Article |

    The stability of the capsid of a virus is strongly affected by its genome. Here the interplay between capsid and genome is explored using native mass spectrometry and atomic force microscopy. A mechanism is proposed to explain how the genome of the Triatoma virus stabilizes the capsid at neutral pH, but triggers disassembly under alkaline conditions.

    • J. Snijder
    • , C. Uetrecht
    •  & W. H. Roos

  • News & Views |

    The combination of addressable synthetic macromolecules with proteins of precise structure and function often leads to materials with unique properties, as is now shown by the efficient multi-site initiation of polymer growth inside the cavity of a virus capsid.

    • Jeroen J. L. M. Cornelissen

  • Article |

    Although most proteins fulfil their role as part of large protein complexes, little is known about the pathways of complex assembly. Here, ion mobility–mass spectrometry is used to monitor and structurally characterize the assembly intermediates of viral protein shells, called capsids, of two major human pathogens, norovirus and hepatitis B virus.

    • Charlotte Uetrecht
    • , Ioana M. Barbu
    •  & Albert J. R. Heck

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