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| Open AccessAn infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli
Bacterial invasion can lead to multiple host cell responses. Here, the authors show that in a model of uropathogenic E. coli, RhoB is upregulated and induces autophagosome formation in a complex with Beclin1 and Hsp90, promoting bacterial clearance.
- Chunhui Miao
- , Mingyu Yu
- & Quan Wang
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Article
| Open AccessHorizontally acquired papGII-containing pathogenicity islands underlie the emergence of invasive uropathogenic Escherichia coli lineages
Escherichia coli is a major cause of urinary tract infection. Here, Biggel et al. provide a phylogenomic analysis of 907 clinical E. coli isolates and identify the P-fimbriae-encoding locus associated with invasive uropathogenic E. coli isolates.
- Michael Biggel
- , Basil B. Xavier
- & Sandra Van Puyvelde
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Article
| Open AccessInvasion of vaginal epithelial cells by uropathogenic Escherichia coli
Uropathogenic E. coli can adhere to vaginal epithelial cells preceding urinary tract infection (UTI). Here, Brannon et al. show that urinary E. coli isolates can not only adhere to, but also invade vaginal cells in mouse UTI models and in clinical samples obtained from women with recurrent UTI.
- John R. Brannon
- , Taryn L. Dunigan
- & Maria Hadjifrangiskou
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| Open AccessGut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection
Urinary tract infections (UTIs) are associated with changes in the gut microbiome. Here, the authors evaluate the relationship between the gut microbiome and development of UTI in kidney transplant patients and show that uropathogenic gut abundance might represent a risk factor for development of bacteriuria and UTI.
- Matthew Magruder
- , Adam N. Sholi
- & John Richard Lee
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Article
| Open AccessPopulation dynamics of an Escherichia coli ST131 lineage during recurrent urinary tract infection
Recurrent urinary tract infections occur in ~ 25% of women. Here, Beatson and colleagues use whole genome sequencing to track the dynamics of an E. coli ST131 clone in a single patient over a 5-year period. This study provides unique insights into pathogen evolution during recurrent urinary infection.
- Brian M. Forde
- , Leah W. Roberts
- & Scott A. Beatson
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LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria
The immune system plays an important role in preventing microbial colonization in the urinary tract but the mechanism of this protection is not completely understood. Here, the authors identify LRRC19 expressed in the kidneys as a pathogen-recognition receptor involved in the immune response to uropathogenic bacteria.
- Xiaomin Su
- , Siping Min
- & Rongcun Yang