Research Highlights |
Featured
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Letter |
Expression of tumour-specific antigens underlies cancer immunoediting
This paper illustrates that immunosurveillance and immunoediting can occur in an oncogene-driven endogenous tumour model provided that the tumours carry strong neoantigens not present in the host.
- Michel DuPage
- , Claire Mazumdar
- & Tyler Jacks
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Letter |
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
Exome analysis of chemical-carcinogen-induced mouse tumours provides evidence for T-cell-mediated immunoselection as a mechanism of immunoediting.
- Hirokazu Matsushita
- , Matthew D. Vesely
- & Robert D. Schreiber
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Research Highlights |
Immune cell boosts cancer
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News & Views |
Final act of senescence
Damaged cells can initiate cancer. To avert this, faulty cells disable their own propagation by undergoing senescence. But for full protection against liver cancer, the senescent cells must be cleared by the immune system. See Letter p.547
- Manuel Serrano
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Letter |
Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules
- Christine Moussion
- & Jean-Philippe Girard
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Letter |
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
- Tae-Won Kang
- , Tetyana Yevsa
- & Lars Zender
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Article |
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
- Christiane A. Opitz
- , Ulrike M. Litzenburger
- & Michael Platten
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News |
Cell therapy fights leukaemia
Patchwork receptors target immune cells against cancer.
- Heidi Ledford
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Letter |
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
- Andrea Facciabene
- , Xiaohui Peng
- & George Coukos
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Research Highlights |
Hide no more, tumour
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Research Highlights |
Cancer: Full immunity needed to fight cancer
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Letter |
Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay
The main reason why tumours are not controlled by the immune system is that they do not express potent tumour rejection antigens. Tumour vaccination aims to provoke a response to any antigens that are expressed. Here, a new approach is described: nonsense-mediated messenger RNA decay in tumour cells is inhibited, leading to the expression of new antigens and to significant inhibition of tumour growth in mice.
- Fernando Pastor
- , Despina Kolonias
- & Eli Gilboa