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Open Access
Featured
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Research Briefing |
Designing air-entrapment interfaces for near-ideal pressure sensors
Pressure sensing is challenging in liquid environments, where typical solid-state sensors do not perform well. A sensor with solid–liquid–liquid–gas multiphasic interfaces — its design inspired by the lotus leaf, and in which a trapped air layer modulates capacitance changes with pressure — is shown to achieve near-ideal pressure sensing and is well suited to liquid environments.
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Review Article |
Hydrogels for RNA delivery
RNA-based therapeutics hold promise for the treatment of several diseases. This Review provides an overview of hydrogels for RNA delivery, discussing how the chemical nature and physical properties of hydrogels can be explored for tailored RNA loading and release, and highlighting the use of these materials in biomedical applications.
- Ruibo Zhong
- , Sepehr Talebian
- & Jinjun Shi
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Article |
An inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection
A bioadhesive hydrogel delivered via inhalation efficiently coats the airway and restricts SARS-CoV-2 virus variant penetration in mice and non-human primates
- Xuan Mei
- , Junlang Li
- & Ke Cheng
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Article |
Species-agnostic polymeric formulations for inhalable messenger RNA delivery to the lung
Screening of hundreds of nanoparticle polymers identifies an effective and low-toxicity formulation for the functional delivery of RNA to the lungs of distinct animal species.
- Laura Rotolo
- , Daryll Vanover
- & Philip J. Santangelo
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Article |
Giant magnetoelastic effect in soft systems for bioelectronics
Micromagnets dispersed in a polymer matrix are used to realize a soft magnetoelastic generator with high magnetomechanical coupling factor, used for wearable and implantable power generation and sensing applications.
- Yihao Zhou
- , Xun Zhao
- & Jun Chen
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Article |
Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues
A functional interfacial material has been developed for soft integration of bioelectronic devices with biological tissues. This has been applied in battery-free optoelectronic systems for deep-brain optogenetics and subdermal phototherapy as well as wireless millimetre-scale pacemakers and flexible multielectrode epicardial arrays.
- Quansan Yang
- , Tong Wei
- & John A. Rogers
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Article |
Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations
Foreign body response can result in failure of biomaterials in vivo. Solvent-free crystals containing anti-fibrotic drugs now show the potential for long-term inhibition of fibrosis on a number of implantable devices in rodents and non-human primates.
- Shady Farah
- , Joshua C. Doloff
- & Daniel G. Anderson
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Review Article |
Designing natural and synthetic immune tissues
Immunotherapy offers a promising approach to treating a range of complications. This Review discusses strategies that employ bioengineering and immunological principles to develop engineered tissues for screening therapeutics and treating diseases.
- Emily A. Gosselin
- , Haleigh B. Eppler
- & Christopher M. Jewell
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Article |
Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates
By studying the immune responses of animals to different types of biomaterial implants, colony stimulating factor-1 receptor is revealed as an important mediator of the foreign body reaction and a possible target for fibrosis inhibition.
- Joshua C. Doloff
- , Omid Veiseh
- & Daniel G. Anderson
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Article |
A fully organic retinal prosthesis restores vision in a rat model of degenerative blindness
A retinal prosthesis fabricated from an organic photovoltaic polymer can restore degenerative blindness in vivo, and over long implantation periods.
- José Fernando Maya-Vetencourt
- , Diego Ghezzi
- & Fabio Benfenati
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Letter |
Single-platelet nanomechanics measured by high-throughput cytometry
A high-throughput hydrogel-based platelet-contraction cytometer is able to quantify single-platelet contraction forces and may function as a clinical diagnostic biophysical biomarker.
- David R. Myers
- , Yongzhi Qiu
- & Wilbur A. Lam
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News & Views |
Leukocyte-like carriers
Drug-loaded liposomes functionalized with proteins from the cell membrane of leukocytes target inflamed tissues without eliciting a substantial immune response.
- Kenneth A. Dawson
- & Yan Yan
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Article |
Biomimetic proteolipid vesicles for targeting inflamed tissues
Lipid nanoparticles incorporating proteins from the leukocyte plasma membrane retain the properties of liposomal formulations and enable delivery of drugs to inflamed tissues.
- R. Molinaro
- , C. Corbo
- & E. Tasciotti
Drinkable in situ-forming tough hydrogels for gastrointestinal therapeutics