Thyroid gland

The thyroid gland is a butterfly-shaped endocrine gland located in the neck underneath the cartilage tissue that forms the Adam's apple. By producing hormones – such as tri-iodothyronine (T3), tetraiodothyronine (T4) and calcitonin – the thyroid gland regulates a number of functions, for example the metabolic rate of cells and blood calcium levels.

Latest Research and Reviews

  • Reviews |

    T3 and T4 are synthesized in the thyroid gland in a process that involves the iodoglycoprotein thyroglobulin. In this Review, we consider the role of thyroglobulin in thyroid hormonogenesis from evolutionary, biochemical, molecular, cellular and physiological angles.

    • Cintia E. Citterio
    • , Héctor M. Targovnik
    •  & Peter Arvan
  • Research | | open

    Thyroid dysfunction is a common public health problem and associated with cardiovascular co-morbidities. Here, the authors carry out genome-wide meta-analysis for thyroid hormone (TH) levels, hyper- and hypothyroidism and identify SLC17A4 as a TH transporter and AADAT as a TH metabolizing enzyme.

    • Alexander Teumer
    • , Layal Chaker
    • , Stefan Groeneweg
    • , Yong Li
    • , Celia Di Munno
    • , Caterina Barbieri
    • , Ulla T. Schultheiss
    • , Michela Traglia
    • , Tarunveer S. Ahluwalia
    • , Masato Akiyama
    • , Emil Vincent R. Appel
    • , Dan E. Arking
    • , Alice Arnold
    • , Arne Astrup
    • , Marian Beekman
    • , John P. Beilby
    • , Sofie Bekaert
    • , Eric Boerwinkle
    • , Suzanne J. Brown
    • , Marc De Buyzere
    • , Purdey J. Campbell
    • , Graziano Ceresini
    • , Charlotte Cerqueira
    • , Francesco Cucca
    • , Ian J. Deary
    • , Joris Deelen
    • , Kai-Uwe Eckardt
    • , Arif B. Ekici
    • , Johan G. Eriksson
    • , Luigi Ferrrucci
    • , Tom Fiers
    • , Edoardo Fiorillo
    • , Ian Ford
    • , Caroline S. Fox
    • , Christian Fuchsberger
    • , Tessel E. Galesloot
    • , Christian Gieger
    • , Martin Gögele
    • , Alessandro De Grandi
    • , Niels Grarup
    • , Karin Halina Greiser
    • , Kadri Haljas
    • , Torben Hansen
    • , Sarah E. Harris
    • , Diana van Heemst
    • , Martin den Heijer
    • , Andrew A. Hicks
    • , Wouter den Hollander
    • , Georg Homuth
    • , Jennie Hui
    • , M. Arfan Ikram
    • , Till Ittermann
    • , Richard A. Jensen
    • , Jiaojiao Jing
    • , J. Wouter Jukema
    • , Eero Kajantie
    • , Yoichiro Kamatani
    • , Elisa Kasbohm
    • , Jean-Marc Kaufman
    • , Lambertus A. Kiemeney
    • , Margreet Kloppenburg
    • , Florian Kronenberg
    • , Michiaki Kubo
    • , Jari Lahti
    • , Bruno Lapauw
    • , Shuo Li
    • , David C. M. Liewald
    • , Behrooz Z. Alizadeh
    • , H. Marike Boezen
    • , Lude Franke
    • , Pim van der Harst
    • , Gerjan Navis
    • , Marianne Rots
    • , Harold Snieder
    • , Morris A. Swertz
    • , Cisca Wijmenga
    • , Ee Mun Lim
    • , Allan Linneberg
    • , Michela Marina
    • , Deborah Mascalzoni
    • , Koichi Matsuda
    • , Daniel Medenwald
    • , Christa Meisinger
    • , Ingrid Meulenbelt
    • , Tim De Meyer
    • , Henriette E. Meyer zu Schwabedissen
    • , Rafael Mikolajczyk
    • , Matthijs Moed
    • , Romana T. Netea-Maier
    • , Ilja M. Nolte
    • , Yukinori Okada
    • , Mauro Pala
    • , Cristian Pattaro
    • , Oluf Pedersen
    • , Astrid Petersmann
    • , Eleonora Porcu
    • , Iris Postmus
    • , Peter P. Pramstaller
    • , Bruce M. Psaty
    • , Yolande F. M. Ramos
    • , Rajesh Rawal
    • , Paul Redmond
    • , J. Brent Richards
    • , Ernst R. Rietzschel
    • , Fernando Rivadeneira
    • , Greet Roef
    • , Jerome I. Rotter
    • , Cinzia F. Sala
    • , David Schlessinger
    • , Elizabeth Selvin
    • , P. Eline Slagboom
    • , Nicole Soranzo
    • , Thorkild I. A. Sørensen
    • , Timothy D. Spector
    • , John M. Starr
    • , David J. Stott
    • , Youri Taes
    • , Daniel Taliun
    • , Toshiko Tanaka
    • , Betina Thuesen
    • , Daniel Tiller
    • , Daniela Toniolo
    • , Andre G. Uitterlinden
    • , W. Edward Visser
    • , John P. Walsh
    • , Scott G. Wilson
    • , Bruce H. R. Wolffenbuttel
    • , Qiong Yang
    • , Hou-Feng Zheng
    • , Anne Cappola
    • , Robin P. Peeters
    • , Silvia Naitza
    • , Henry Völzke
    • , Serena Sanna
    • , Anna Köttgen
    • , Theo J. Visser
    •  & Marco Medici

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