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The secret life of the protein VASP
Biomolecular condensates compartmentalize and concentrate cellular components without the delimitation of a lipid membrane. The protein VASP is now shown to condense, resulting in the reorganization of actin, a key component of the cell cytoskeleton.
- Julie Plastino
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Letter
| Open AccessSequence-dependent surface condensation of a pioneer transcription factor on DNA
A DNA-binding protein condenses on DNA via a switch-like transition. Surface condensation occurs at preferential DNA locations suggesting collective sequence readout and enabling sequence-specificity robustness with respect to protein concentration.
- Jose A. Morin
- , Sina Wittmann
- & Stephan W. Grill
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Article |
Physical determinants of the self-replication of protein fibrils
Certain proteins are capable of self-replicating, including those associated with Alzheimer’s disease. Simulations now pinpoint the adsorption of monomeric proteins onto protein fibril surfaces as the mechanism responsible for self-replication.
- Anđela Šarić
- , Alexander K. Buell
- & Daan Frenkel