Structure determination articles within Nature Chemistry

Featured

• Article | 27 July 2020

  Acyltransferase that catalyses the condensation of polyketide and peptide moieties of goadvionin hybrid lipopeptides

  The biosynthesis of goadvionins—hybrid lipopeptide antibiotics—is not fully understood. An unusual acyltransferase, GdvG, has now been identified and shown to catalyse a condensation reaction between an acyl-carrier-protein-tethered very-long-chain fatty acid and an eight-residue ribosomally synthesized and post-translationally modified peptide. The position of functional groups in the very-long acyl chain have been determined by tandem mass spectrometry.

  • Ryosuke Kozakai
  • , Takuto Ono
  •  & Hiroyasu Onaka

• Article | 01 January 2018

  An integrated native mass spectrometry and top-down proteomics method that connects sequence to structure and function of macromolecular complexes

  An integrated native mass spectrometry and top-down proteomics method using Fourier transform ion cyclotron resonance has been developed for the characterization of macromolecular protein complexes. This approach directly yields primary to quaternary structural information in a single native top-down experiment.

  • Huilin Li
  • , Hong Hanh Nguyen
  •  & Joseph A. Loo

• Research Highlights | 18 December 2012

  Adjudazol assignment

  • Stephen Davey

• News & Views | 23 September 2010

  Molecules under the microscope

  A series of scanning probe microscopy experiments combined with density functional theory calculations have now been used to unambiguously determine the structure of a marine natural product. Can this method become generally useful for the determination of the structure of natural products?

  • John W. Blunt