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Modelling post-implantation human development to yolk sac blood emergence
A genetically inducible stem cell-derived embryoid model of early post-implantation human embryogenesis captures the codevelopment of embryonic tissue and extra-embryonic endoderm and mesoderm niche with early haematopoiesis, with potential for drug testing and disease modelling.
- Joshua Hislop
- , Qi Song
- & Mo R. Ebrahimkhani
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Article
| Open Access
Single-cell brain organoid screening identifies developmental defects in autism
We develop a high-throughput CRISPR screening system in cerebral organoids and identify vulnerable cell types and gene regulatory networks associated with autism spectrum disorder from single-cell transcriptomes and chromatin modalities.
- Chong Li
- , Jonas Simon Fleck
- & Juergen A. Knoblich
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Article |
Generation of functional oocytes from male mice in vitro
Mouse induced pluripotent stem cells derived from differentiated fibroblasts could be converted from male (XY) to female (XX), resulting in cells that could form oocytes and give rise to offspring after fertilization.
- Kenta Murakami
- , Nobuhiko Hamazaki
- & Katsuhiko Hayashi
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Article |
Hair-bearing human skin generated entirely from pluripotent stem cells
Skin organoids generated in vitro from human pluripotent stem cells form complex, multilayered skin tissue with hair follicles, sebaceous glands and neural circuitry, and integrate with endogenous skin when grafted onto immunocompromised mice.
- Jiyoon Lee
- , Cyrus C. Rabbani
- & Karl R. Koehler
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Construction of a human cell landscape at single-cell level
Single-cell RNA sequencing is used to generate a dataset covering all major human organs in both adult and fetal stages, enabling comparison with similar datasets for mouse tissues.
- Xiaoping Han
- , Ziming Zhou
- & Guoji Guo
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Letter |
Controlled modelling of human epiblast and amnion development using stem cells
Landmarks of early stages of human embryogenesis can be recapitulated in a highly controllable and scalable fashion by culturing human pluripotent stem cells in a microfluidic device.
- Yi Zheng
- , Xufeng Xue
- & Jianping Fu
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Article |
Charting cellular identity during human in vitro β-cell differentiation
Single-cell transcriptional profiling of in vitro human pancreatic β-cell differentiation reveals progenitor and terminal fates, produces a detailed time course of endocrine induction and underpins a lineage model.
- Adrian Veres
- , Aubrey L. Faust
- & Douglas A. Melton
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Article |
CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells
These preclinical studies outline a CRISPR-based methodology for correcting β-globin gene mutations in haematopoietic stem cells to advance the development of next-generation therapies for β-haemoglobinopathies.
- Daniel P. Dever
- , Rasmus O. Bak
- & Matthew H. Porteus
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Letter |
Diverse and heritable lineage imprinting of early haematopoietic progenitors
In vivo ‘cellular barcoding’ shows that early haematopoietic progenitors are heterogeneous in the cell types that they produce, and this is partly due to an ‘imprinting’ of fate in progenitors, including for a separate dendritic cell lineage.
- Shalin H. Naik
- , Leïla Perié
- & Ton N. Schumacher
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Research Highlights |
Human eye parts in a dish
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News |
Stem cells take root in drug development
Increasing use by industry showcases stem cell technology as research tool.
- Daniel Cressey
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Research Highlights |
Cell transplants repair colon
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News Q&A |
Stem-cell boss urges communication
Incoming chairman wants public to know about California stem-cell agency's work.
- Erika Check Hayden
An epigenetic barrier sets the timing of human neuronal maturation