Spinocerebellar ataxia articles within Nature

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• Letter | 12 April 2017

  Antisense oligonucleotide therapy for spinocerebellar ataxia type 2

  Antisense oligonucleotides against ATXN2 improved motor neuron function and restored firing frequency in cerebellar Purkinje cells in mouse models of spinocerebellar ataxia type 2.

  • Daniel R. Scoles
  • , Pratap Meera
  •  & Stefan M. Pulst

• Article | 29 May 2013

  RAS–MAPK–MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1

  Cross-species genetic screens reveal that decreased mitogen-activated protein kinase signalling reduces polyglutamine-expanded ataxin 1 levels and toxicity in models of spinocerebellar ataxia type 1.

  • Jeehye Park
  • , Ismael Al-Ramahi
  •  & Huda Y. Zoghbi