Small intestine articles within Nature Communications

Featured

  • Article
    | Open Access

    Interleukin (IL)-22 is critical in ameliorating obesity-induced metabolic disorders; however, it is unclear where IL-22 acts to mediate these outcomes. Here, the authors show in tissue-specific IL-22 receptor knockout mice a key role of intestinal epithelium-specific IL-22RA1 signaling in regulating intestinal metabolism and alleviating obesity-associated disorders.

    • Stephen J. Gaudino
    • , Ankita Singh
    •  & Pawan Kumar

  • Article
    | Open Access

    DNA demethylation is known to be critical for the development and function of many tissues. Here the authors show that it is also required for intestinal lineage differentiation, and that mice lacking DNA demethylases have altered microbiomes and a predisposition to inflammation.

    • Ihab Ansari
    • , Llorenç Solé-Boldo
    •  & Yehudit Bergman

  • Article
    | Open Access

    Fibroblastic reticular cells (FRCs) support localisation of immune cells in secondary lymphoid tissues but less is known about the lamina propria. Here the authors use scRNA-seq and intestinal infection to characterise FRCs in the intestinal lamina propria and show specialised niches that foster innate lymphoid cells during homeostasis and infection.

    • Hung-Wei Cheng
    • , Urs Mörbe
    •  & Burkhard Ludewig

  • Article
    | Open Access

    Intestinal surface changes in size and function, but what propels these alterations is unknown. Here, the authors show that food excess increases the gut absorptive capacity, and that in presence of dietary lipids, intestinal PPARα is indispensable for the adaptive increase in villi length and function.

    • Ozren Stojanović
    • , Jordi Altirriba
    •  & Mirko Trajkovski

  • Article
    | Open Access

    Intestinal aging is associated with declines in structure and absorption of nutrients. Here, the authors show that aging related intestinal decline is mediated by activation of the mTORC1-p38MAPK-p53 pathway in intestinal stem cells and can be ameliorated by abrogating mTORC1 or p38MAPK activity.

    • Dan He
    • , Hongguang Wu
    •  & Baojie Li

  • Article
    | Open Access

    The histone variant, H2A.Z is known to regulate gene expression and cell proliferation. Here the authors show that H2A.Z has a central role in the control of intestinal epithelial homeostasis in mice, by preventing terminal differentiation of intestinal progenitors.

    • Jérémie Rispal
    • , Lucie Baron
    •  & Fabrice Escaffit

  • Article
    | Open Access

    Innate lymphoid cells (ILC), including natural killer (NK) cells, are important innate immune regulators. Here the authors show that, in human infant intestines, CD103+Eomes+ NK cells are the predominant ILC population, but are replaced gradually by Eomes+ T cells, while NKp44+ NK cells persist in adult intestines.

    • Adrian F. Sagebiel
    • , Fenja Steinert
    •  & Madeleine J. Bunders

  • Article
    | Open Access

    There is a need for humanised grafts to treat patients with intestinal failure. Here, the authors generate intestinal grafts by recellularizing native intestinal matrix with human induced pluripotent stem cell-derived epithelium and human endothelium, and show nutrient absorption after transplantation in rats.

    • Kentaro Kitano
    • , Dana M. Schwartz
    •  & Harald C. Ott

  • Article |

    The segmentation motor activity of the small intestine is believed to be a result of alternating inhibitory and excitatory neural activity. Huizinga et al.show that the segmentation motor pattern is in fact a result of phase–amplitude interactions of slow-wave activities generated by two networks of interstitial cells of Cajal.

    • Jan D. Huizinga
    • , Ji-Hong Chen
    •  & David Chen

Browse broader subjects

Browse narrower subjects

Browse Small intestine across other nature.com journals