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Skin models are experimental systems that recreate aspects of human skin physiology, function or disease. They include in vitro methods, ex vivo skin cultures and animal models, especially mice and fish.
A protocol for broad-spectrum, in vivo fluorescent labeling and tracking of extracellular matrix proteins through the systemic or local application of N-hydroxysuccinimide esters. This flexible approach can be adapted for a variety of organ systems and wounding models.
The transcription factor ΔNp63 is a master regulator of epithelial development and integrity of stratified epithelial tissues. Here, the authors unveiled the lncRNA NEAT1 as an additional player of the highly complex regulatory network by which ΔNp63 controls epidermal homeostasis.
A crucial role for glucose metabolism has been identified in wound repair and in the pathogenesis of chronic inflammatory skin diseases, indicating that targeting metabolism is an approach for treating psoriasis.
Topically applied spherical nucleic acids targeting an intracellular mRNA biomarker associated with abnormal scarring enable the fluorescent detection of abnormal scars during wound healing.
M. Bishr Omary reminds us of the three articles that first uncovered a causative link between mutations in intermediate filaments (specifically, keratin 14) and human diseases.
