News & Views |
Featured
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Article |
DNA sequencing using electrical conductance measurements of a DNA polymerase
DNA molecules can be sequenced by monitoring the electrical conductance of a phi29 DNA polymerase as it incorporates unlabelled nucleotides into a template strand of DNA.
- Yu-Shiun Chen
- , Chia-Hui Lee
- & G. Steven Huang
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Letter |
Fast DNA sequencing with a graphene-based nanochannel device
Calculations show that two-dimensional conductance spectra in a graphene nanoribbon placed across a fluidic nanochannel can be used to rapidly and reliably sequence DNA.
- Seung Kyu Min
- , Woo Youn Kim
- & Kwang S. Kim
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Editorial |
Quantum steps to better sequencing
Nanopores and electron tunnelling offer a potentially revolutionary approach to DNA sequencing.
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News & Views |
Sequencing at the end of the tunnel
Electron tunnelling can be used to identify single bases in a short DNA oligomer.
- Massimiliano Di Ventra
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News & Views |
Detecting methylation with force
An atomic force microscope with antibodies attached to its tip can be used to determine methylation patterns in individual DNA strands by making hundreds of force spectroscopy measurements.
- Piotr E. Marszalek
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News & Views |
Read with quantum mechanics
Electron tunnelling can be used to selectively identify the basic constituents of DNA, indicating that the approach could be used to efficiently read a DNA sequence.
- Thomas Thundat