RNAi articles within Nature

Featured

• Technology Feature | 21 April 2010

  Homing in on delivery

  The scientific community now seems convinced that small RNAs will become therapies, if new tools can help these large molecules to make it safely into cells. Monya Baker reports.

  • Monya Baker

• Letter | 15 April 2010

  Functional genomic screen for modulators of ciliogenesis and cilium length

  Primary cilia are tiny hair-like structures expressed on the surface of eukaryotic cells. They participate in a range of processes, such as sensing the extracellular environment and regulating signalling pathways during development. Here, a functional genomic screen is presented that used RNA interference to identify human genes involved in controlling ciliogenesis. Several positive and negative ciliogenesis modulators with broad-ranging functions were found.

  • Joon Kim
  • , Ji Eun Lee
  •  & Joseph G. Gleeson

• Letter | 17 January 2010

  Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication

  High mutation rates in the influenza A virus facilitate the generation of viral escape mutants, rendering vaccines and drugs potentially ineffective, but targeting host cell determinants could prevent viral escape. Here, 287 human host cell genes influencing influenza A virus replication are found using a genome-wide RNA interference screen. An independent assay is then used to investigate overlap between genes necessary for different viral strains.

  • Alexander Karlas
  • , Nikolaus Machuy
  •  & Thomas F. Meyer