News & Views |
Featured
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Research Highlight |
Use of urine albumin and cystatin C levels improves risk stratification in chronic kidney disease
- Rebecca Ireland
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News & Views |
Transplant tourism—an update regarding the realities
A recent article exposes the ongoing industry of transplant tourism in China, where foreign patients can receive vendor organs recovered from executed prisoners. Concerning data reveal the long-term complications of kidney transplant tourism, particularly the increased risk of malignancy. These findings relay an important message to transplant communities and physicians worldwide.
- Francis L. Delmonico
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News & Views |
Donor risk scores: can they predict renal transplant outcomes?
In light of recent proposed changes to the deceased donor allocation policy in the USA, considerable interest has arisen in the development of assessment tools to grade donor organ quality. Kahu and colleagues have suggested a new donor risk score that incorporates 10 distinct donor characteristics, correlating their presence with baseline histologic findings and graft outcomes.
- Edmund Huang
- , Gabriel Danovitch
- & Suphamai Bunnapradist
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Research Highlight |
Sustained proteinuria and dyslipidemia are risk factors for progressive CKD in patients with lupus nephritis
- Steven E. Bradshaw
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News & Views |
Kidney markers predict mortality in patients with HIV disease
Individuals with HIV disease frequently experience kidney dysfunction, which is accompanied by an increased risk of cardiovascular disease and death. Choi et al. have found that albuminuria and an estimated glomerular filtration rate of <60 ml/min/1.73 m2, estimated using serum cystatin C level, accounted for 17% of the population-attributable 5-year mortality risk in a cohort of patients with HIV infection.
- Jeffrey B. Kopp
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Research Highlight |
Low ghrelin levels in dialysis patients increases mortality risk
- Helene Myrvang
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News & Views |
World Kidney Day 2011: protect your kidneys, save your heart
March 10, 2011 will mark the 6th World Kidney Day, an annual event jointly sponsored by the International Society of Nephrology and the International Federation of Kidney Foundations. World Kidney Day aims to raise awareness among both the general public and government health officials about the dangers of kidney disease, especially chronic kidney disease.
- William G. Couser
- & Miguel C. Riella
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Opinion |
Challenges of conducting a trial of uric-acid-lowering therapy in CKD
Although the relationship between asymptomatic hyperuricemia and chronic kidney disease is not fully understood, data from small studies indicate that reducing high serum urate level may slow disease progression. In this Perspectives article, Badve and colleagues propose that a multicenter pilot randomized controlled trial be performed to investigate the effects of uric-acid-lowering therapy in patients with CKD.
- Sunil V. Badve
- , Fiona Brown
- & Vlado Perkovic
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News & Views |
Strength in numbers—predicting long-term transplant outcomes
Prediction of renal allograft outcomes has been elusive despite the number of risk factors that correlate with graft failure. Using a large French transplant database and novel statistical methods, Foucher et al. have produced a predictive scoring system for graft failure worthy of study in other populations.
- William E. Braun
- & Jesse D. Schold
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Review Article |
Prenatal programming—effects on blood pressure and renal function
Disturbed intrauterine organogenesis has long-term consequences on organ function in adulthood, so-called prenatal programming. In this Review, Ritz and colleagues outline the concept of prenatal programming and, in particular, describe its role in kidney disease and hypertension. Intrauterine growth restriction (IUGR) as a predictor of renal and cardiovascular disease in adulthood, and the potential of low birthweight as a (clinical) surrogate marker of IUGR, are also discussed.
- Eberhard Ritz
- , Kerstin Amann
- & Kerstin Benz
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Review Article |
Sudden cardiac death in chronic kidney disease: epidemiology and prevention
Annual cardiovascular mortality rates are much higher in patients with chronic kidney disease (CKD) than in the general population. Sudden cardiac death rate increases with CKD stage and could be responsible for 60% of cardiac deaths in patients undergoing dialysis. In this Review, the authors describe the epidemiology and risk factors for sudden cardiac death in patients with CKD and discuss potential therapeutic approaches.
- M. Khaled Shamseddin
- & Patrick S. Parfrey
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News & Views |
Sudden cardiac death: stratifying risk in dialysis patients
Patients with end-stage renal disease have a heightened risk of cardiovascular morbidity and mortality. Cardiac arrest causes around one-quarter of deaths in this population, and a recent study has investigated whether echocardiographic parameters and serum biomarkers can be used to predict the risk of sudden cardiac death in patients on peritoneal dialysis.
- Rod Passman
- & Charles A. Herzog
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News & Views |
Hyperhomocysteinemia: a renal and cardiovascular risk factor?
One recent trial failed to show any beneficial effect of homocysteine lowering using vitamin B therapy on survival and cardiovascular events in patients with end-stage renal disease, and results of another study in patients with early-stage diabetic nephropathy actually suggested that vitamin B therapy has harmful effects. Do these findings mark the end of the era of studies investigating homocysteine lowering in patients with chronic kidney disease?
- Carmine Zoccali
- & Kitty J. Jager
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Research Highlight |
Study reveals link between autonomic imbalance and kidney disease
- Susan J. Allison
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Research Highlight |
Meta-analysis confirms relationship between eGFR, albuminuria and risk of mortality
- Susan J. Allison
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Research Highlight |
Serum uric acid level is associated with early GFR loss in type 1 diabetes
- Susan J. Allison
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Research Highlight |
Increased mortality risk in renal transplant recipients with ATG-induced CD4+ T-cell lymphopenia
- Rebecca Ireland
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News & Views |
Is acute kidney injury a risk factor for long-term mortality?
Acute kidney injury seems to have sequelae long beyond the index hospitalization. A new study suggests that even after adjusting for the impact of subsequent chronic kidney disease, acute kidney injury is associated with an increased risk of death.
- Kathleen D. Liu
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Review Article |
Cardiovascular risk in the peritoneal dialysis patient
Cardiovascular disease is the most frequent cause of death in patients on peritoneal dialysis. In this Review, Krediet and Balafa describe cardiovascular risk factors that may affect the general population, those that are related to end-stage renal disease, and those that are specific to patients on peritoneal dialysis. The authors also discuss how these factors may be modified by changes in residual kidney function and/or peritoneal dialysis.
- Raymond T. Krediet
- & Olga Balafa
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Review Article |
Risk factors for new-onset diabetes after kidney transplantation
New-onset diabetes after transplantation (NODAT) is a common complication following kidney transplantation and is associated with adverse patient and graft outcomes. This Review discusses the current understanding of the risk factors associated with NODAT and transplant-associated hyperglycemia. The authors suggest that a dynamic approach to the surveillance and attenuation of transplantation-associated hyperglycemia may help to improve the outcomes of patients with NODAT.
- Adnan Sharif
- & Keshwar Baboolal
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Research Highlight |
Proteinuria is an important indicator of adverse outcomes in CKD
- Susan J. Allison
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News & Views |
Masked hypertension: a risk factor in children with CKD
Masked hypertension—which is present in about 25% of adult patients initially classified as normotensive—is associated with left ventricular hypertrophy and is a well-documented marker of cardiovascular risk in adults. A recent study has found that masked hypertension is also an important and underdiagnosed cardiovascular risk factor in children.
- Robert H. Mak
- & George Bakris
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Research Highlight |
Diabetes and LV mass predict progression of prehypertension to hypertension
- Susan J. Allison
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Research Highlight |
Dialysis is associated with cardiovascular and noncardiovascular mortality
- Susan J. Allison
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Research Highlight |
Rapid renal function decline is associated with an increased risk of cardiovascular complications
- Rebecca Ireland
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Research Highlight |
Prehypertension and obesity are associated with increased risk of treated ESRD and CKD death in a European cohort
- Baldo Lucchese
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Staging CKD: can we rely on estimated GFRs?
Native renal cysts linked to RCC in transplanted kidneys
Does uric acid level affect renal and cardiovascular risk?
Cystatin C and albuminuria predict mortality in diabetes