Research Highlight |
Featured
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Research Highlight |
Blood group linked to risk of cancer in patients with Barrett esophagus
- Rachel Thompson
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Research Highlight |
UV protection and dermatological screening needed for IBD patients exposed to thiopurines
- Natalie J. Wood
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Review Article |
Clostridium difficile infection: epidemiology, risk factors and management
Clostridium difficileis as an important health-care-associated pathogen and is linked to significant morbidity, economic burden, and even mortality. A dramatic rise in the incidence ofC. difficileinfections has occurred over the past decade and new at-risk populations are emerging. This Review discusses recent changes in the epidemiology of CDI and its risk factors, examines the evidence behind various treatment regimens and management strategies and suggests measures for infection control.
- Ashwin N. Ananthakrishnan
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Review Article |
Genome-wide association studies and genetic risk assessment of liver diseases
The latest genome-wide association studies in large cohorts of patients with a range of liver diseases have provided new insights into the pathophysiology of these illnesses. This Review outlines the role of genetic testing in monogenic liver diseases, compiles the results of genome-wide association studies in hepatology and discusses new concepts in the genetics of liver diseases in general.
- Marcin Krawczyk
- , Roman Müllenbach
- & Frank Lammert
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News & Views |
Hyperplastic polyposis syndrome and risk of colorectal cancer
Hyperplastic polyposis syndrome is a widely accepted, but poorly understood, risk factor for colorectal cancer. A recent report has laid the foundations for improving the management of patients with this enigmatic disorder by identifying the features associated with colorectal cancer risk, as well as estimating the magnitude of this risk.
- Joanne P. Young
- & Susan Parry
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Review Article |
Hepatocellular carcinoma: a global view
Hepatocellular carcinoma is a global health problem, although developing countries are disproportionally affected. About three-quarters of hepatocellular carcinomas are attributed to chronic HBV and HCV infections. This Review provides an overview of the global variation in hepatocellular carcinoma incidence and etiology, as well as the prevention, screening, diagnosis and treatment of this cancer.
- Ju Dong Yang
- & Lewis R. Roberts
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Review Article |
The role of alcohol and smoking in pancreatitis
Chronic alcohol use has been linked to pancreatitis for over a century, but its role in the disease has only been recently elucidated. This Review focuses on what is known from animal models and association studies conducted in humans about the relationship between alcohol consumption, smoking, and chronic pancreatitis. The authors discuss the incidence, pathogenesis and etiology of pancreatitis as well as mechanisms of disease.
- Dhiraj Yadav
- & David C. Whitcomb
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Research Highlight |
High dietary intake of linoleic acid more than doubles the risk of ulcerative colitis
- Natalie J. Wood
Regular, prolonged aspirin use and an increased risk of Crohn's disease