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Open Access
Featured
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Letter |
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
Accumulation of fumarate resulting from mutations in fumarate hydratase,which are associated with renal and other cancers, is shown to induce epithelial-to-mesenchymal transition—a process associated with cancer initiation.
- Marco Sciacovelli
- , Emanuel Gonçalves
- & Christian Frezza
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Article
| Open Access
Comprehensive molecular characterization of clear cell renal cell carcinoma
The Cancer Genome Atlas Research Network reports an integrative analysis of more than 400 samples of clear cell renal cell carcinoma based on genomic, DNA methylation, RNA and proteomic characterisation; frequent mutations were identified in the PI(3)K/AKT pathway, suggesting this pathway might be a potential therapeutic target, among the findings is also a demonstration of metabolic remodelling which correlates with tumour stage and severity.
- Chad J. Creighton
- , Margaret Morgan
- & Heidi J. Sofia.
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Letter |
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase
- Christian Frezza
- , Liang Zheng
- & Eyal Gottlieb
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Letter |
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
Clear cell renal carcinoma, the most common form of adult kidney cancer, is often characterized by the presence of inactivating mutations in the VHL gene. A large survey for somatic mutations now identifies inactivating mutations in two genes encoding enzymes involved in histone modification, highlighting the role of mutations in components of the chromatin modification machinery in human cancer.
- Gillian L. Dalgliesh
- , Kyle Furge
- & P. Andrew Futreal
The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer