Renal cell carcinoma

Definition

Renal cell carcinoma (RCC) refers to a heterogenous group of cancers that originate in the proximal convoluted tubule of the kidney. The three most common forms of RCC are clear cell RCC, papillary RCC and chromophobe RCC.

Latest Research and Reviews

  • Research | | open

    Renal cell carcinoma (RCC) is a common and aggressive malignancy. Here, the authors generate two mouse models of the most common RCC subtypes: the human papillary RCC through MYC activation and clear cell RCC through MYC activation combined with Vhl and Cdkn2a deletion.

    • Sean T. Bailey
    • , Aleisha M. Smith
    • , Jordan Kardos
    • , Sara E. Wobker
    • , Harper L. Wilson
    • , Bhavani Krishnan
    • , Ryoichi Saito
    • , Hyo Jin Lee
    • , Jing Zhang
    • , Samuel C. Eaton
    • , Lindsay A. Williams
    • , Ujjawal Manocha
    • , Dorien J. Peters
    • , Xinchao Pan
    • , Thomas J. Carroll
    • , Dean W. Felsher
    • , Vonn Walter
    • , Qing Zhang
    • , Joel S. Parker
    • , Jen Jen Yeh
    • , Richard A. Moffitt
    • , Janet Y. Leung
    •  & William Y. Kim
  • Research |

    Through combined deletion of Vhl, Trp53 and Rb1 in renal epithelial cells, the authors develop a new mouse model of renal cell carcinoma that recapitulates the cellular and molecular features of a large proportion of human tumors. This model uncovers a role for primary-cilium-related genes in the development of the disease and provides a reliable platform for preclinical therapeutic studies.

    • Sabine Harlander
    • , Désirée Schönenberger
    • , Nora C Toussaint
    • , Michael Prummer
    • , Antonella Catalano
    • , Laura Brandt
    • , Holger Moch
    • , Peter J Wild
    •  & Ian J Frew
  • Reviews |

    Clear cell renal cell carcinoma is associated with reprogramming of metabolic pathways including glucose and fatty acid metabolism and the tricarboxylic acid cycle. Here, the authors discuss these reprogrammed pathways and the opportunities they provide for new therapies, imaging modalities and biomarkers.

    • Hiromi I. Wettersten
    • , Omran Abu Aboud
    • , Primo N. Lara Jr
    •  & Robert H. Weiss
  • Research | | open

    Cell lines are central to cancer research, but knowing which cell lines are the best representative of actual tumours is a major challenge. Here the authors provide a resource assessment of 65 renal cell lines to assist researchers in selecting suitable lines for studying specific renal carcinoma subtypes.

    • Rileen Sinha
    • , Andrew G. Winer
    • , Michael Chevinsky
    • , Christopher Jakubowski
    • , Ying-Bei Chen
    • , Yiyu Dong
    • , Satish K. Tickoo
    • , Victor E. Reuter
    • , Paul Russo
    • , Jonathan A. Coleman
    • , Chris Sander
    • , James J. Hsieh
    •  & A. Ari Hakimi
  • Reviews |

    Renal cell carcinoma (RCC) is a neoplasm of the renal epithelium and accounts for >90% of kidney cancers. Cancer genomic studies have identified numerous molecular events that lead to RCC and marked intra-tumour heterogeneity, which have prognostic and therapeutic relevance. In this Primer, the authors describe these advances, as well as highlight the considerable advances in the systemic treatment of metastatic RCC.

    • James J. Hsieh
    • , Mark P. Purdue
    • , Sabina Signoretti
    • , Charles Swanton
    • , Laurence Albiges
    • , Manuela Schmidinger
    • , Daniel Y. Heng
    • , James Larkin
    •  & Vincenzo Ficarra