Article
|
Open Access
Featured
-
-
Article
| Open Access
A plant-derived natural photosynthetic system for improving cell anabolism
Proof of concept of the viability of a plant-derived photosynthetic system based on nanothylakoid units encapsulated in a chondrocyte membrane to enhance cell anabolism in chondrocytes is demonstrated.
- Pengfei Chen
- , Xin Liu
- & Xianfeng Lin
-
Article |
Charting cellular identity during human in vitro β-cell differentiation
Single-cell transcriptional profiling of in vitro human pancreatic β-cell differentiation reveals progenitor and terminal fates, produces a detailed time course of endocrine induction and underpins a lineage model.
- Adrian Veres
- , Aubrey L. Faust
- & Douglas A. Melton
-
Article |
Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells
Islet non-β-cells from non-diabetic and diabetic human donors are modified via the transcription factors PDX1 and MAFA to produce and secrete insulin in response to glucose.
- Kenichiro Furuyama
- , Simona Chera
- & Pedro L. Herrera
-
Letter |
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model
In a preclinical study, dopaminergic neurons derived from human induced pluripotent stem cells were implanted into a primate model of Parkinson’s disease, where they were found to exhibit long-term survival, function as mid-brain dopaminergic neurons, and increase spontaneous movements.
- Tetsuhiro Kikuchi
- , Asuka Morizane
- & Jun Takahashi
-
Article |
Interspecies organogenesis generates autologous functional islets
The authors inject mouse pluripotent stem cells into pancreatogenesis-disabled rat blastocysts and thereby generate rats with mouse pancreata from which the islets, when transplanted into mice, can provide a long-term cure for symptoms of diabetes, without continuous immunosuppression.
- Tomoyuki Yamaguchi
- , Hideyuki Sato
- & Hiromitsu Nakauchi
-
Outlook |
Regenerative medicine: Rebuilding the backbone
Surgeons can help fix damaged vertebrae, but could an infusion of cells in a bioengineered material grow to replace a damaged spinal column?
- Mike May
-
Letter |
Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme
The pancreatic lineage is used as a model for embryonic-stem-cell differentiation, and shows that co-culture with organ-matched mesenchyme permits proliferation and self-renewal of progenitors, enabling an expansion of more than a million-fold for human endodermal cells with full retention of developmental potential.
- Julie B. Sneddon
- , Malgorzata Borowiak
- & Douglas A. Melton
-
News |
African spiny mice can regrow lost skin
Rodents are first mammals observed regenerating tissue.
- Zoe Cormier
-
Research Highlights |
Nanofibres foster blood vessels
-
News & Views |
Reprogramming the injured heart
When the heart is injured, the muscle does not regenerate and scars are produced. This process can be attenuated in the hearts of live mice by forcing scar-forming cells to become muscle cells. See Articles p.593 & p.599
- Nathan J. Palpant
- & Charles E. Murry
-
News |
South Korea steps up stem-cell work
Regenerative medicine gets cash boost but stricter regulations are needed to ensure safety.
- Soo Bin Park
-
News |
Regenerative medicine repairs mice from top to toe
Three separate studies in mice show normal function can be restored to hair, eye and heart cells.
- Leila Haghighat
-
Research Highlights |
Cell transplants repair colon
-
News & Views |
Organ recital in a dish
It is difficult to recapitulate organ development in vitro, especially when interactions between tissues are essential. Nonetheless, researchers have now achieved this for the pituitary gland. See Article p.57
- Karine Rizzoti
- & Robin Lovell-Badge
-
Letter |
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells
- Kosuke Yusa
- , S. Tamir Rashid
- & Ludovic Vallier
-
Editorial |
Start small, think big
The United Kingdom and others must not overlook the potential for nanotechnology to boost regenerative medicine.
-
News & Views |
Bespoke cells for the human brain
Human skin cells have been directly converted into neurons, an achievement that could lead to the cell-based treatment of neurodegenerative disorders. But the road ahead remains long and tortuous. See Letters p.220, p.224 & p.228
- Michael Sendtner
-
Research Highlights |
Edited stem cells yield healthy mice
-
News & Views |
Drawing breath after spinal injury
New work on a rat model suggests that, after spinal-cord injury, restoration of sustained and robust respiratory function is possible using strategies that promote both neuronal plasticity and regeneration. See Article p.196
- Katherine Zukor
- & Zhigang He
-
Books & Arts |
Stem cells: The clash of hype, hope and stem cells
A revealing book investigates the politicization of regenerative medicine, finds Gilberto Corbellini.
- Gilberto Corbellini
-
News & Views |
Muscle for a damaged heart
When cardiac muscle cells die during a heart attack, this can lead to heart failure and even death. It now emerges that stem cells of the 'sheet' enveloping the heart can be coaxed to form new muscle after such an event. See Letter p.640
- Vincent Christoffels
-
Letter |
Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors
- Sayaka Sekiya
- & Atsushi Suzuki
-
News |
Stem cells patch up 'broken' heart
Cell reactivation in mouse hearts repairs muscle after heart attack.
- Marian Turner
-
Letter |
Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors
- Pengyu Huang
- , Zhiying He
- & Lijian Hui
-
Research Highlights |
New ways to change fates
-
-
Letter |
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
- Amar Sahay
- , Kimberly N. Scobie
- & René Hen
-
Research Highlights |
Robo protein guide for cell transplants
-
News |
Cellular 'alchemy' transforms skin into blood
Direct conversion of cell types could offer safer, simpler treatments than stem cells.
- Ewen Callaway
-
News & Views |
Heart redevelopment
Scientists report the conversion of one type of differentiated cell, the fibroblast, into another — the cardiomyocyte. This approach may find use in regenerative strategies for the repair of damaged hearts.
- Richard P. Harvey
-
-
News & Views |
An eye to treating blindness
Work on stem cells is one of the hottest research areas in biology. But are such studies of any therapeutic value? Fortunately, yes, as is evident from successes in treating blindness.
- Elena Ezhkova
- & Elaine Fuchs
-
Research Highlights |
Developmental biology: Heads or tails
-
News & Views |
Cell reprogramming gets direct
In a feat of biological wizardry, one type of differentiated cell has been directly converted into another, completely distinct type. Notably, the approach does not require a stem-cell intermediate stage.
- Cory R. Nicholas
- & Arnold R. Kriegstein
CGRP sensory neurons promote tissue healing via neutrophils and macrophages
DIY eye
FDA challenges stem-cell clinic