The first demonstration of a mechanism for active sorting of anterograde cargo in the Golgi via protein palmitoylation.

Newly synthesised lysosomal proteins are sorted from other cargo on the secretory pathway for delivery to endolysosomal compartments. A study now shows that the Batten disease protein, CLN8, acts as a recycling receptor to sort soluble lysosomal enzymes for export from the endoplasmic reticulum to the Golgi.

Protein translocation across bacterial membranes can take many routes through dedicated transport machines. A new study finds that Salmonella Typhi utilizes a distinct pathway to translocate typhoid toxin across the peptidoglycan layer and prime the bacterium for host intoxication.

This interview in our series highlighting early-career researchers is with Gregory Lavieu, INSERM investigator at Institut Curie in Paris, France. In this series, we aim to bring attention to the diversity and individual stories of early-career researchers (defined as postdoctoral scientists through to tenure, or the equivalent). Gregory joined the institute as a permanent researcher in October 2017 to unlock the mysteries of extracellular vesicles. Here he discusses the many unanswered questions in the field as well as his unconventional path to his current position.