Featured
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Article
| Open AccessBinding and dimerization of PGLa peptides in anionic lipid bilayer studied by replica exchange molecular dynamics
- Steven R. Bowers
- , Christopher Lockhart
- & Dmitri K. Klimov
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Article
| Open AccessAmyloidogenic 60–71 deletion/ValThr insertion mutation of apolipoprotein A-I generates a new aggregation-prone segment that promotes nucleation through entropic effects
- Norihiro Namba
- , Takashi Ohgita
- & Hiroyuki Saito
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Article
| Open AccessStress-mediated aggregation of disease-associated proteins in amyloid bodies
- Sahil Chandhok
- , Lionel Pereira
- & Timothy E. Audas
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Article
| Open AccessIntramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein
- Takashi Ohgita
- , Hiroki Kono
- & Hiroyuki Saito
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Article
| Open AccessCarprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation
- Donghee Lee
- , Ji Eun Ryoo
- & YoungSoo Kim
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Article
| Open AccessThe GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces cerevisiae
- Rebecca Josefson
- , Navinder Kumar
- & Thomas Nyström
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Article
| Open AccessLabel-free autofluorescence lifetime reveals the structural dynamics of ataxin-3 inside droplets formed via liquid–liquid phase separation
- Uchu Matsuura
- , Shinya Tahara
- & Takakazu Nakabayashi
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Article
| Open AccessFood protein-derived amyloids do not accelerate amyloid β aggregation
- M. Mahafuzur Rahman
- , Rodrigo Sanches Pires
- & Christofer Lendel
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Editorial
| Open AccessAmyloids in synthetic applications
More than a century after the first description of amyloids by Alois Alzheimer, and despite the enormous research efforts since then, the field is still full of surprises. While searching for answers to questions for example on the driving force, mechanism, and regulation of amyloidogenesis, or on the structure, physiological and pathological roles of different amyloid aggregates, unexpected properties are regularly revealed, broadening their application possibilities. This Collection aims to focus on the beneficial sides of amyloid formation, primarily exploring the potential use of amyloids in material science, bioengineering, and synthetic chemistry.
- Marianna Török
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Article
| Open AccessTwin-arginine translocase component TatB performs folding quality control via a chaperone-like activity
- May N. Taw
- , Jason T. Boock
- & Matthew P. DeLisa
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Article
| Open AccessA comparative study of unpasteurized and pasteurized frozen whole hen eggs using size-exclusion chromatography and small-angle X-ray scattering
- Yoshiki Oka
- , Hiroko Yukawa
- & Munehito Arai
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Article
| Open AccessDifferences in interaction lead to the formation of different types of insulin amyloid
- Wakako Mori
- , Ryosuke Kawakami
- & Tamotsu Zako
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Article
| Open AccessMechanisms of enhanced aggregation and fibril formation of Parkinson’s disease-related variants of α-synuclein
- Takashi Ohgita
- , Norihiro Namba
- & Hiroyuki Saito
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Article
| Open AccessProteome-wide landscape of solubility limits in a bacterial cell
- Ádám Györkei
- , Lejla Daruka
- & Balázs Papp
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Article
| Open AccessAcute-phase serum amyloid A for early detection of hepatocellular carcinoma in cirrhotic patients with low AFP level
- Jin-Lin Wu
- , Tung-Hung Su
- & Yun-Ru Chen
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Article
| Open AccessProteomic analysis of heat-stable proteins revealed an increased proportion of proteins with compositionally biased regions
- Hongsun Park
- , Tomoyuki Yamanaka
- & Nobuyuki Nukina
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Article
| Open AccessElectric-field induced modulation of amorphous protein aggregates: polarization, deformation, and reorientation
- Kyongok Kang
- & Florian Platten
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Article
| Open AccessA human tau seeded neuronal cell model recapitulates molecular responses associated with Alzheimer’s disease
- Elena Ficulle
- , Sarubini Kananathan
- & Suchira Bose
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Article
| Open AccessHoney bee sHSP are responsive to diverse proteostatic stresses and potentially promising biomarkers of honey bee stress
- Samantha R. Shih
- , Dunay M. Bach
- & Jonathan W. Snow
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Article
| Open AccessThe chaperone HSPB1 prepares protein aggregates for resolubilization by HSP70
- Conrado C. Gonçalves
- , Itai Sharon
- & Jason C. Young
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Article
| Open AccessEquine pituitary pars intermedia dysfunction: a spontaneous model of synucleinopathy
- Jessica S. Fortin
- , Ashley A. Hetak
- & Harold C. Schott II
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Article
| Open AccessExogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans
- Michele Perni
- , Benedetta Mannini
- & Michele Vendruscolo
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Article
| Open AccessNon-coding RNA suppresses FUS aggregation caused by mechanistic shear stress on pipetting in a sequence-dependent manner
- Nesreen Hamad
- , Ryoma Yoneda
- & Masato Katahira
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Article
| Open AccessPolyQ-expanded proteins impair cellular proteostasis of ataxin-3 through sequestering the co-chaperone HSJ1 into aggregates
- Hong-Wei Yue
- , Jun-Ye Hong
- & Hong-Yu Hu
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Article
| Open AccessIdentification of critical amino acid residues in the regulatory N-terminal domain of PMEL
- Susan M. Mitchell
- , Morven Graham
- & Ralf M. Leonhardt
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Article
| Open AccessShear-mediated sol-gel transition of regenerated silk allows the formation of Janus-like microgels
- Zenon Toprakcioglu
- & Tuomas P. J. Knowles
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Article
| Open AccessThe less conserved metal-binding site in human CRISP1 remains sensitive to zinc ions to permit protein oligomerization
- Jie Sheng
- , Bart M. Gadella
- & J. Bernd Helms
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Article
| Open AccessClinically-identified C-terminal mutations in fibulin-3 are prone to misfolding and destabilization
- DaNae R. Woodard
- , Emi Nakahara
- & John D. Hulleman
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Article
| Open AccessTethering-induced destabilization and ATP-binding for tandem RRM domains of ALS-causing TDP-43 and hnRNPA1
- Mei Dang
- , Yifan Li
- & Jianxing Song
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Article
| Open AccessThe retinal toxicity profile towards assemblies of Amyloid-β indicate the predominant pathophysiological activity of oligomeric species
- Efrat Naaman
- , Sarah Ya’ari
- & Shiri Zayit-Soudry
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Article
| Open Accessα-Synuclein promotes IAPP fibril formation in vitro and β-cell amyloid formation in vivo in mice
- Marija Mucibabic
- , Pär Steneberg
- & Helena Edlund
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Article
| Open AccessCMT-3 targets different α-synuclein aggregates mitigating their toxic and inflammogenic effects
- Florencia González-Lizárraga
- , Diego Ploper
- & Rosana Chehín
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Article
| Open AccessThe secondary structural difference between Lewy body and glial cytoplasmic inclusion in autopsy brain with synchrotron FTIR micro-spectroscopy
- Katsuya Araki
- , Naoto Yagi
- & Hideki Mochizuki
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Article
| Open AccessIodine staining as a useful probe for distinguishing insulin amyloid polymorphs
- Takato Hiramatsu
- , Naoki Yamamoto
- & Eri Chatani
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Article
| Open AccessNetwork Hamiltonian models reveal pathways to amyloid fibril formation
- Yue Yu
- , Gianmarc Grazioli
- & Carter T. Butts
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Article
| Open AccessGallic acid oxidation products alter the formation pathway of insulin amyloid fibrils
- Andrius Sakalauskas
- , Mantas Ziaunys
- & Vytautas Smirnovas
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Article
| Open Access1.2 MV/cm pulsed electric fields promote transthyretin aggregate degradation
- Gen Urabe
- , Takashi Sato
- & Sunao Katsuki
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Article
| Open AccessCyclophilin D binds to the acidic C-terminus region of α-Synuclein and affects its aggregation characteristics
- James Torpey
- , Jillian Madine
- & Lu-Yun Lian
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Article
| Open AccessOn the Aggregation and Nucleation Mechanism of the Monoclonal Antibody Anti-CD20 Near Liquid-Liquid Phase Separation (LLPS)
- Elvira Pantuso
- , Teresa F. Mastropietro
- & Gianluca Di Profio
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Article
| Open AccessProteomics-Based Approach Identifies Altered ER Domain Properties by ALS-Linked VAPB Mutation
- Tomoyuki Yamanaka
- , Risa Nishiyama
- & Nobuyuki Nukina
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Article
| Open AccessPolymorphic Aβ42 fibrils adopt similar secondary structure but differ in cross-strand side chain stacking interactions within the same β-sheet
- Hongsu Wang
- , Lan Duo
- & Zhefeng Guo
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Article
| Open AccessFormation of distinct prion protein amyloid fibrils under identical experimental conditions
- Mantas Ziaunys
- , Tomas Sneideris
- & Vytautas Smirnovas
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Article
| Open AccessTaurine Induces an Ordered but Functionally Inactive Conformation in Intrinsically Disordered Casein Proteins
- Mohd Younus Bhat
- , Laishram Rajendrakumar Singh
- & Tanveer Ali Dar
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Article
| Open AccessTransition between protein-like and polymer-like dynamic behavior: Internal friction in unfolded apomyoglobin depends on denaturing conditions
- Livia Balacescu
- , Tobias E. Schrader
- & Andreas M. Stadler
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Article
| Open AccessLiquid-like droplet formation by tumor suppressor p53 induced by multivalent electrostatic interactions between two disordered domains
- Kiyoto Kamagata
- , Saori Kanbayashi
- & Satoshi Takahashi
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Article
| Open AccessThe N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State
- Matteo Runfola
- , Alfonso De Simone
- & Giuliana Fusco
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Article
| Open AccessAmyloidophilic Molecule Interactions on the Surface of Insulin Fibrils: Cooperative Binding and Fluorescence Quenching
- Mantas Ziaunys
- , Kamile Mikalauskaite
- & Vytautas Smirnovas
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Article
| Open AccessRNA-binding protein FXR1 is presented in rat brain in amyloid form
- Julia V. Sopova
- , Elena I. Koshel
- & Alexey P. Galkin
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Article
| Open AccessUnpacking the aggregation-oligomerization-fibrillization process of naturally-occurring hIAPP amyloid oligomers isolated directly from sera of children with obesity or diabetes mellitus
- Myriam M. Altamirano-Bustamante
- , Nelly F. Altamirano-Bustamante
- & Raúl Calzada-León