Physiology articles within Nature Chemistry

Featured

• Article | 19 December 2010

  Ion mobility–mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation

  Amyloid cascades leading to peptide β-sheet fibrils are central to many diseases. Intermediate assemblies were recently identified as the toxic agents, but obtaining structural details of these early oligomers has largely been unsuccessful with traditional techniques. Here, ion mobility methods provide evidence for structural transitions from random to β-sheet assembly.

  • Christian Bleiholder
  • , Nicholas F. Dupuis
  •  & Michael T. Bowers

• Research Highlights | 08 January 2010

  H₂S in hibernation

  A synthetic functional model of the oxygen reduction site in the enzyme cytochrome c oxidase has been used to investigate the effects of hydrogen sulfide on respiration.

  • Stephen Davey