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Open Access
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Matters Arising
| Open AccessThe case for standardizing gene nomenclature in vertebrates
- Fiona M. McCarthy
- , Tamsin E. M. Jones
- & Elspeth A. Bruford
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Article
| Open AccessPandemic-scale phylogenomics reveals the SARS-CoV-2 recombination landscape
A new phylogenomic method is developed that can detect recombinations in virus lineages in pandemic-scale datasets.
- Yatish Turakhia
- , Bryan Thornlow
- & Russell Corbett-Detig
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Article
| Open AccessDiverse mutational landscapes in human lymphocytes
Sequencing of individual human lymphocyte clones shows that they are highly prone to mutations, with higher burdens in memory cells than in naive cells arising from mutational processes associated with differentiation and tissue residency.
- Heather E. Machado
- , Emily Mitchell
- & Peter J. Campbell
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Extensive phylogenies of human development inferred from somatic mutations
Somatic mutations obtained from laser microdissected biopsies of human tissues are used to reconstruct the developmental phylogenies of these tissues back to the zygote.
- Tim H. H. Coorens
- , Luiza Moore
- & Michael R. Stratton
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Article |
Functionally uncoupled transcription–translation in Bacillus subtilis
In Bacillus subtilis, unlike in Escherichia coli, transcription and translation of genes are not tightly coupled, and pioneering ribosomes lag substantially behind RNA polymerases.
- Grace E. Johnson
- , Jean-Benoît Lalanne
- & Gene-Wei Li
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Article
| Open AccessOne thousand plant transcriptomes and the phylogenomics of green plants
The One Thousand Plant Transcriptomes Initiative provides a robust phylogenomic framework for examining green plant evolution that comprises the transcriptomes and genomes of diverse species of green plants.
- James H. Leebens-Mack
- , Michael S. Barker
- & Gane Ka-Shu Wong
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Population dynamics of normal human blood inferred from somatic mutations
Analysis of blood from a healthy human show that haematopoietic stem cells increase rapidly in numbers through early life, reaching a stable plateau in adulthood, and contribute to myeloid and B lymphocyte populations throughout life.
- Henry Lee-Six
- , Nina Friesgaard Øbro
- & Peter J. Campbell
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Letter |
Zika virus evolution and spread in the Americas
One hundred and ten Zika virus genomes from ten countries and territories involved in the Zika virus epidemic reveal rapid expansion of the epidemic within Brazil and multiple introductions to other regions.
- Hayden C. Metsky
- , Christian B. Matranga
- & Pardis C. Sabeti
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Article
| Open AccessThe genome of Eucalyptus grandis
The Eucalyptus grandis genome has been sequenced, revealing the greatest number of tandem duplications of any plant genome sequenced so far, and the highest diversity of genes for specialized metabolites that act as chemical defence and provide unique pharmaceutical oils; genome sequencing of the sister species E. globulus and a set of inbred E. grandis tree genomes reveals dynamic genome evolution and hotspots of inbreeding depression.
- Alexander A. Myburg
- , Dario Grattapaglia
- & Jeremy Schmutz
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Letter |
Independent evolution of striated muscles in cnidarians and bilaterians
This phylogenomic study shows that core muscle proteins were already present in unicellular organisms before the origin of multicellular animals, and supports a convergent evolutionary model for striated muscles in which new proteins are added to ancient contractile apparatus during independent evolution of bilaterians and some non-bilaterians, resulting in very similar ultrastructures.
- Patrick R. H. Steinmetz
- , Johanna E. M. Kraus
- & Ulrich Technau
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Letter |
Proto-genes and de novo gene birth
Novel protein-coding genes can arise either from pre-existing genes or de novo; here it is shown that functional genes emerge de novo through transitory proto-genes generated by widespread translational activity in non-genic sequences.
- Anne-Ruxandra Carvunis
- , Thomas Rolland
- & Marc Vidal
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Letter |
Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing
Next-generation sequencing is used here to analyse Plasmodium falciparum genome variation directly from clinical blood samples, as well as cultured isolates, from Africa, Asia and Oceania.
- Magnus Manske
- , Olivo Miotto
- & Dominic P. Kwiatkowski
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Letter |
Resolving the evolutionary relationships of molluscs with phylogenomic tools
- Stephen A. Smith
- , Nerida G. Wilson
- & Casey W. Dunn
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Letter |
Phylogenomics reveals deep molluscan relationships
- Kevin M. Kocot
- , Johanna T. Cannon
- & Kenneth M. Halanych
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News & Views |
Annelid who's who
The origin of the annelids is buried in distant evolutionary time. A molecular phylogeny resolves their deep family interrelationships and provides a picture of their 'urannelid' ancestor. See Letter p.95
- Detlev Arendt
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