Perturbations articles within Nature Communications

Featured

• Article
  17 August 2022 | Open Access

  Halogenation of tyrosine perturbs large-scale protein self-organization

  Sun et al. has studied the genetically encodable halotyrosines in proteins of the prokaryotic cell division machinery to elucidate the general role of halogenation in cellular lifespan and oxidative damage-induced diseases such as aging and cancer.

  • Huan Sun
  • , Haiyang Jia
  •  & Nediljko Budisa

• Article
  17 November 2020 | Open Access

  Sensing the allosteric force

  Almost all allosteric systems are large multi-domain proteins which complicates the investigation of the mechanism in atomistic detail. Here authors designed a small allosteric protein system using the photocontrollable PDZ3 domain, that allows controlling allostery between the binding and allosteric site in both directions.

  • Olga Bozovic
  • , Brankica Jankovic
  •  & Peter Hamm

• Article
  03 October 2016 | Open Access

  Localized force application reveals mechanically sensitive domains of Piezo1

  Piezo ion channels transduce mechanical forces into biological signals. Here, the authors use magnetic tweezers to pull specific regions of Piezo1, identifying mechanically sensitive domains that are essential for channel activation and inactivation.

  • Jason Wu
  • , Raman Goyal
  •  & Jörg Grandl

• Article
  19 June 2015 | Open Access

  Direct interaction between centralspindlin and PRC1 reinforces mechanical resilience of the central spindle

  The central spindle is an anti parallel bundle of microtubules that forms between segregating chromosomes and links the two halves of the mitotic spindle. Lee et al.reveal that interaction between two microtubule bundling proteins at the central spindle confers robustness to cortical pulling forces.

  • Kian-Yong Lee
  • , Behrooz Esmaeili
  •  & Masanori Mishima

• Article
  15 June 2015 | Open Access

  Physical principles of membrane remodelling during cell mechanoadaptation

  Variations in cell shape must be accommodated by the cell membrane, but how the membrane adjusts to changes in area and volume is not known. Here the authors show that the membrane responds in a nearly instantaneous, purely physical manner involving the flattening or generation of membrane invaginations.

  • Anita Joanna Kosmalska
  • , Laura Casares
  •  & Pere Roca-Cusachs

• Article | 28 February 2012

  Perturbation of sodium channel structure by an inherited Long QT Syndrome mutation

  Perturbation of the cardiac voltage-gated sodium channel, Na_V1.5, by drugs or inherited mutation can underlie and trigger cardiac arrhythmias. Here, the role of the Na_V1.5 carboxy terminus in channel inactivation is investigated, and structural details of an arrhythmia associated H6 mutant are reported.

  • Ian W. Glaaser
  • , Jeremiah D. Osteen
  •  & Robert S. Kass

• Article | 09 August 2011

  Delay-induced anomalous fluctuations in intracellular regulation

  Direct negative feedback decreases fluctuations in homoeostatic control, but intracellular regulatory systems are indirect. Here, an analytical expression is derived to show that indirect feedback in transcription and translation leads to more fluctuations for intermediate delays but not for long delays.

  • Andreas Grönlund
  • , Per Lötstedt
  •  & Johan Elf

• Article | 19 July 2011

  Ranking stability and super-stable nodes in complex networks

  Pagerank is widely used to rank web content; however, it is unknown how network topology affects its performance. The authors demonstrate that, in random networks, pagerank is sensitive to perturbations in topology, whereas scale-free networks contain a few super-stable nodes whose ranking is exceptionally stable.

  • Gourab Ghoshal
  •  & Albert-László Barabási