Osteopontin is an acidic phosphoprotein produced by osteoblasts and other cell types. Osteopontin is an extracellular protein that has a cell-adhesion sequence (RGD) that mediates its interaction with integrins and extracellular matrix components. It has functions in biomineralization of bone, chemotaxis, apoptosis and cell activation in immunity.
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Research | | openBritish Journal of Cancer 112, 729–738