Organocatalysis

Organocatalysis is a type of catalysis where the catalyst in the chemical reaction is an organic (non-metallic) compound. The catalysts operate both through the transient formation of covalent bonds, such as in enamine and imminium catalysis, as well as through non-covalent interactions, such as in hydrogen bonding catalysis.

Latest Research and Reviews

News and Comment

  • News and Views |

    Two recent back-to-back meetings conveyed a common set of ongoing challenges for the fields of organocatalysis, photoredox catalysis and photochemistry.

    • Craig P. Johnston
    Nature Chemistry 11, 400-401
  • News and Views |

    Control over the length and composition of polymers is key to controlling their properties. Now, a photoswitchable catalyst is shown to allow external control over reaction rates, chain lengths and even polymer composition in ring-opening polymerizations.

    • Paula K. Kuroishi
    •  & Andrew P. Dove
    Nature Catalysis 1, 486-487
  • News and Views |

    Catalytic methods are among the most valuable tools for sustainable synthesis. Domino catalysis enables multiple reactions to be combined so that synthetic efficiency may begin to approach that of nature, but significant challenges remain before this promising approach can fulfil the needs of pharmaceutical and materials chemistry.

    • Thomas Broja
    • , Patrick J. W. Fuchs
    •  & Kirsten Zeitler
    Nature Chemistry 7, 950-951
  • News and Views |

    Preparing powerful reactive intermediates such as enolates and homoenolates for C–C bond formation used to require strong bases and stoichiometric reagents. They can now be catalytically generated from α-functionalized aldehydes or even from saturated esters under mild conditions using N-heterocyclic carbene catalysts.

    • Jeffrey W. Bode
    Nature Chemistry 5, 813-815