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How the feedforward information from the nose and feedback from the cortex interact in the olfactory bulb is not fully understood. Here, by imaging olfactory sensory neurons and cortical projections to the olfactory bulb, the authors show that sensory transformations contained within both streams.
This study demonstrates the decomposition of an odour compound in olfactory perception and central neural representation and establishes a direct correspondence between the coding of submolecular chemical features and odour quality.
Whether and how cannabinoid type-1 receptors impact sensory functions in vivo is largely unknown. Here, authors show that their endogenous activity controls network dynamics in the olfactory piriform cortex and the ability of mice to detect odorants.
Perszyk et al. identify the neural basis for odour-imagery ability and show that it indirectly predicts weight-gain susceptibility through a mechanism that is dependent on food-cue reactivity.
The authors used precision functional imaging and computational modeling to uncover the structure of perceptual odor coding in the human brain. Olfactory areas differ in the granularity, dimensionality and subjectivity of perceptual coding.
In mice, the endocannabinoid system inhibits glutamatergic signalling from the olfactory cortex to the main olfactory bulb after fasting, increasing the detection of food odours and, consequently, enhancing food consumption.
Learned odor discrimination and generalization are reflected in patterns of ensemble activity in anterior piriform cortex, where learned discrimination between two odors reduces the correlation between their induced patterns.