Nucleosomes articles within Nature Methods

Featured

• News & Views | 20 May 2022

  Mapping beads on strings

  DiMeLo-seq leverages immunotethered DNA methyltransferases with long-read sequencing to map the locations of chromatin proteins in their natural context.

  • Kami Ahmad

• Research Highlight | 04 February 2021

  Sequencing DNA bendability

  Loop-seq is a high-throughput sequencing assay that measures DNA looping and can help explain how DNA bendability contributes to nucleosome organization.

  • Lei Tang

• Research Highlights | 30 January 2018

  Humanized yeast—erasing 1.3 billion years of evolution

  Cellular engineering that allows budding yeast to survive with the four core human histones opens the door to exploring the function of histone variants and their modifications.

  • Nicole Rusk

• Article | 03 November 2013

  Coupling transcription factor occupancy to nucleosome architecture with DNase-FLASH

  By separately sequencing and mapping smaller and larger DNase I fragments from the same DNase I digestion experiment, the approach allows simultaneous profiling of transcription factor footprints relative to nucleosome occupancy.

  • Jeff Vierstra
  • , Hao Wang
  •  & John A Stamatoyannopoulos