Review Article |
Featured
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Review Article |
Balancing opioid analgesia with the risk of nonmedical opioid use in patients with cancer
Patients with cancer might be at a higher risk of nonmedical opioid use than was previously thought; however, opioid analgesics remain the gold standard to treat cancer-related pain. The authors of this Review examine the role of opioids in cancer-related pain, the risk of substance use disorder and methods to achieve the right balance between both to ensure safe opioid use.
- Joseph Arthur
- & Eduardo Bruera
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Review Article |
Mechanisms of neuroblastoma regression
Recent studies of neuroblastoma have shed light on the dramatic heterogeneity in its clinical behaviour, which spans from spontaneous regression or differentiation to relentless disease progression. This Review describes the different mechanisms of spontaneous neuroblastoma regression—including neurotrophin deprivation, humoral or cellular immunity, loss of telomerase activity and alterations in epigenetic regulation—and the consequent therapeutic approaches, as a better understanding of these mechanisms might help to identify optimal therapies.
- Garrett M. Brodeur
- & Rochelle Bagatell
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Research Highlight |
Stereotactic radiosurgery—new options for multiple brain metastases?
- Alessia Errico
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Review Article |
Neurosurgical management of metastases in the central nervous system
Rates of central nervous system (CNS) involvement in metastatic cancer are believed to be increasing. The neurosurgical treatment of patients with metastatic cancer is an integral component of multimodality therapy for brain and spinal metastases. This Review discusses data from current randomized clinical trials that examine the role of neurosurgical intervention in the treatment of patients with CNS metastases.
- Elizabeth B. Claus
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News & Views |
Neurocognitive considerations in the treatment of brain metastases
The results of a randomized, controlled trial investigating the neurocognitive effects of stereotactic radiosurgery (SRS), with or without whole-brain radiation therapy (WBRT), to treat brain metastases demonstrated a significant reduction in learning and memory, associated with the addition of WBRT to SRS. The results indicate that SRS monotherapy is an effective and safe initial management strategy for brain metastases.
- Nicholas F. Marko
- & Robert J. Weil
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