Featured
-
-
Article |
Simultaneous profiling of spatial gene expression and chromatin accessibility during mouse brain development
MISAR-seq combines spatial-ATAC-seq and RNA-seq for spatial profiling of both chromatin accessibility and gene expression, as demonstrated in the developing mouse brain.
- Fuqing Jiang
- , Xin Zhou
- & Guangdun Peng
-
Article |
Femtosecond laser microdissection for isolation of regenerating C. elegans neurons for single-cell RNA sequencing
Femtosecond laser microdissection enables transcriptomic analyses of single neurons based on their phenotype.
- Peisen Zhao
- , Sudip Mondal
- & Adela Ben-Yakar
-
News & Views |
New dual-channel system records lineage in high definition
Introducing iTracer, a system for long-term measurement of lineage dynamics at high resolution.
- Kunal Jindal
- , Sadie VanHorn
- & Samantha A. Morris
-
Article
| Open Access
Lineage recording in human cerebral organoids
A dual-channel recording system for high-resolution lineage tracing.
- Zhisong He
- , Ashley Maynard
- & Barbara Treutlein
-
-
Article |
Engineering of human brain organoids with a functional vascular-like system
Expression of ETV2 in human cortical organoids induces the formation of vascular-like networks, which reduces cell death within organoids and increases their functional maturation.
- Bilal Cakir
- , Yangfei Xiang
- & In-Hyun Park
-
Brief Communication |
DeActs: genetically encoded tools for perturbing the actin cytoskeleton in single cells
DeActs are genetically encoded tools that perturb the actin cytoskeleton. In contrast to drugs such as latrunculin, they can be targeted to specific cell types, which is demonstrated in the developing mouse brain and in Caenorhabditis elegans.
- Martin Harterink
- , Marta Esteves da Silva
- & J Bradley Zuchero
-
Technology Feature |
Stem cells: a dish of neurons
Labs can generate neurons from pluripotent stem cells to study basic biology and to model disease. Protocols are getting more robust, and labs add personal preferences.
- Vivien Marx
-
Research Highlights |
The developing human brain—modeled in a dish
Stem cells grown in three-dimensional cultures self-organize into tissues that resemble the developing human brain.
- Erika Pastrana
-
Research Highlights |
Predicting neurogenesis
Expression of a microRNA cluster predicts whether or not a particular human pluripotent stem cell line will differentiate well into neurons.
- Natalie de Souza
Comprehensive spatiotemporal mapping of single-cell lineages in developing mouse brain by CRISPR-based barcoding