Multihormonal system disorders articles within Nature Communications

Featured

• Article
  08 August 2022 | Open Access

  Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer

  Cancer-associated cachexia is characterized by loss of body weight, skeletal muscle and adipose tissue which relates to higher mortality in cancer patients. Here, the authors show in a lung cancer murine model that both ActRIIB signalling inhibition and restoring appetite are necessary to revert cachexia and improve survival in female mice.

  • Andre Lima Queiroz
  • , Ezequiel Dantas
  •  & Marcus D. Goncalves

• Article
  23 April 2021 | Open Access

  COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system

  The SARS-CoV-2 receptor ACE2 is involved in the Renin-Angiotensin-Aldosterone System (RAAS). Over-activation of RAAS in swine results in a disease state similar to that of COVID-19 in human patients, suggesting that COVID-19 pathophysiology may be driven, at least in part, by an imbalance of this hormonal system.

  • Susanne Rysz
  • , Jonathan Al-Saadi
  •  & Johan Lundberg

• Article
  10 December 2019 | Open Access

  Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease

  The adipokine leptin modulates intestinal inflammation in mice. Here the authors describe a patient with inflammatory bowel disease and lipodystrophy, providing evidence that leptin aggravates intestinal inflammation with proinflammatory effects on leukocytes that are reversible by TNFα blockade.

  • Jörn F. Ziegler
  • , Chotima Böttcher
  •  & Carl Weidinger