Featured
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Letter |
Dynein harnesses active fluctuations of microtubules for faster movement
The motor protein dynein is associated with microtubule force generation in the cell; how it interacts with cytoskeletal fluctuations is still an open question. Here the authors show that dynein can harness these fluctuations to generate power and move faster towards the minus-end of microtubules.
- Yasin Ezber
- , Vladislav Belyy
- & Ahmet Yildiz
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News & Views |
Stronger than they look
An experimental study of living cells suggests that single myosin molecules are capable of generating unusually large forces. The observation is supported by a theoretical model — and demonstrates the complexity of in vivo force generation.
- Andrew W. Holle
- & Ralf Kemkemer
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News & Views |
Driven to peak
A curious peak in the distribution describing stochastic switching in bacterial motility had researchers confounded. But a careful study performed under varying mechanical conditions has now revealed that the breaking of detailed balance is to blame.
- Yuhai Tu
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Article |
Non-equilibrium effect in the allosteric regulation of the bacterial flagellar switch
Flagellated bacteria move by alternately rotating their flagella clockwise and counterclockwise with dynamics that are shown here to be torque dependent. This non-equilibrium effect increases motor sensitivity as the torque increases.
- Fangbin Wang
- , Hui Shi
- & Junhua Yuan
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Article |
Deterministic patterns in cell motility
Cell motility is typically described as a random walk due to the presence of noise. But a dynamical model suggests that dendritic cells move deterministically, alternating between fast and slow motility, and exhibiting periodic polarity reversals.
- Ido Lavi
- , Matthieu Piel
- & Nir S. Gov
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Letter |
The flagellar motor of Caulobacter crescentus generates more torque when a cell swims backwards
Certain bacteria swim by rotating a single helical filament, moving forwards and backwards with similar speeds. The discovery that the torque is not equal in both directions links them to multifilament species with opposite filament handedness.
- Pushkar P. Lele
- , Thibault Roland
- & Howard C. Berg