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| Open AccessProgrammed cell death 11 modulates but not entirely relies on p53-HDM2 loop to facilitate G2/M transition in colorectal cancer cells
- Li Ding
- , Yujie Xu
- & Xinyue Zhang
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Article
| Open AccessAIFM2 promotes hepatocellular carcinoma metastasis by enhancing mitochondrial biogenesis through activation of SIRT1/PGC-1α signaling
- Sanxing Guo
- , Fengying Li
- & Junqi Liu
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Review Article
| Open AccessDiscovery of neddylation E2s inhibitors with therapeutic activity
- MAA Mamun
- , Ying Liu
- & Hong-Min Liu
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Article
| Open AccessPKD phosphorylation and COP9/Signalosome modulate intracellular Spry2 protein stability
- Natalia Martínez
- , Teresa Gragera
- & José M. Rojas-Cabañeros
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Article
| Open AccessPELI1 and EGFR cooperate to promote breast cancer metastasis
- Jie Qi
- , Guangsen Xu
- & Baobing Zhao
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Article
| Open AccessGenerating in vitro models of NTRK-fusion mesenchymal neoplasia as tools for investigating kinase oncogenic activation and response to targeted therapy
- Fabio Vanoli
- , Laurie Herviou
- & Cristina R. Antonescu
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Article
| Open AccessNon-genetic stratification reveals epigenetic heterogeneity and identifies vulnerabilities of glycolysis addiction in lung adenocarcinoma subtype
- Xuming Song
- , Te Zhang
- & Feng Jiang
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Article
| Open AccessPFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma
- Emma Phillips
- , Jörg Balss
- & Violaine Goidts
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Article
| Open AccessTumor-derived miR-130b-3p induces cancer-associated fibroblast activation by targeting SPIN90 in luminal A breast cancer
- Suyeon Ahn
- , Ahreum Kwon
- & Woo Keun Song
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Article
| Open AccessMethylation of HBP1 by PRMT1 promotes tumor progression by regulating actin cytoskeleton remodeling
- Jiyin Wang
- , Ruixiang Yang
- & Xiaowei Zhang
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Article
| Open AccessZNF655 accelerates progression of pancreatic cancer by promoting the binding of E2F1 and CDK1
- Zhuo Shao
- , Chenggang Li
- & Hua Fan
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Article
| Open AccessThe E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling
- Xiaomin Ma
- , Xiaoxiao Ma
- & Lihui Han
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Article
| Open AccessNNMT promotes the progression of intrahepatic cholangiocarcinoma by regulating aerobic glycolysis via the EGFR-STAT3 axis
- Shounan Lu
- , Shanjia Ke
- & Yong Ma
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Article
| Open AccessMicroRNA-21 is immunosuppressive and pro-metastatic via separate mechanisms
- Lap Hing Chi
- , Ryan S. N. Cross
- & Robin L. Anderson
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Article
| Open AccessAberrant APOBEC3C expression induces characteristic genomic instability in pancreatic ductal adenocarcinoma
- Yunzhen Qian
- , Yitao Gong
- & Chen Liu
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Article
| Open AccessThe TIP60-ATM axis regulates replication fork stability in BRCA-deficient cells
- Emily M. Schleicher
- , Ashna Dhoonmoon
- & George-Lucian Moldovan
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Article
| Open AccessFusion protein-driven IGF-IR/PI3K/AKT signals deregulate Hippo pathway promoting oncogenic cooperation of YAP1 and FUS-DDIT3 in myxoid liposarcoma
- Ruth Berthold
- , Ilka Isfort
- & Wolfgang Hartmann
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Article
| Open AccessPSMC2 promotes the progression of gastric cancer via induction of RPS15A/mTOR pathway
- Tao Liu
- , Junling Zhang
- & Zhen Yang
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Article
| Open AccessmiR-32 promotes MYC-driven prostate cancer
- Mauro Scaravilli
- , Sonja Koivukoski
- & Leena Latonen
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Article
| Open AccessAnti-miR-135/SPOCK1 axis antagonizes the influence of metabolism on drug response in intestinal/colon tumour organoids
- Roya Babaei-Jadidi
- , Hossein Kashfi
- & Abdolrahman S. Nateri
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Article
| Open AccessACTL6A suppresses p21Cip1 tumor suppressor expression to maintain an aggressive mesothelioma cancer cell phenotype
- Suruchi Shrestha
- , Gautam Adhikary
- & Richard L. Eckert
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Article
| Open AccessPost-transcriptional screen of cancer amplified genes identifies ERBB2/Her2 signaling as AU-rich mRNA stability-promoting pathway
- Jenan Al-Matouq
- , Latifa Al-Haj
- & Khalid S. A. Khabar
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Article
| Open AccessE2F1 and epigenetic modifiers orchestrate breast cancer progression by regulating oxygen-dependent ESRP1 expression
- Cheemala Ashok
- , Neha Ahuja
- & Sanjeev Shukla
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Article
| Open AccessCtBP1/2 differentially regulate genomic stability and DNA repair pathway in high-grade serous ovarian cancer cell
- YingYing He
- , Zhicheng He
- & Shubai Liu
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Article
| Open AccessPRMT6 activates cyclin D1 expression in conjunction with the transcription factor LEF1
- Lucas Schneider
- , Stefanie Herkt
- & Joern Lausen
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Article
| Open AccessModerate DNA hypomethylation suppresses intestinal tumorigenesis by promoting caspase-3 expression and apoptosis
- Xiaoya Duan
- , Yuanyong Huang
- & Jiemin Wong
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Article
| Open AccessThe metastasis suppressor protein NM23-H1 modulates the PI3K-AKT axis through interaction with the p110α catalytic subunit
- Francesco Paolo Pennino
- , Masanao Murakami
- & Erle S. Robertson
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Article
| Open AccessCARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo
- Laura Israël
- , Anton Glück
- & Frédéric Bornancin
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Article
| Open AccessC20orf204, a hepatocellular carcinoma-specific protein interacts with nucleolin and promotes cell proliferation
- Sebastian Burbano De Lara
- , Doan Duy Hai Tran
- & Teruko Tamura
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Article
| Open AccessMusashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC)
- Petr Makhov
- , Igor Bychkov
- & Yanis Boumber
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Article
| Open AccessUSP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer
- Fabiana Alejandra Rossi
- , Juliana Haydeé Enriqué Steinberg
- & Mario Rossi
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Article
| Open AccessRNF8 ubiquitinates RecQL4 and promotes its dissociation from DNA double strand breaks
- Qunsong Tan
- , Kaifeng Niu
- & Yongliang Zhao
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Article
| Open AccessA novel role of MNT as a negative regulator of REL and the NF-κB pathway
- Judit Liaño-Pons
- , M. Carmen Lafita-Navarro
- & Javier León
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Article
| Open AccessThe HLTF–PARP1 interaction in the progression and stability of damaged replication forks caused by methyl methanesulfonate
- Jia-Lin Shiu
- , Cheng-Kuei Wu
- & Hungjiun Liaw
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Review Article
| Open AccessThe functional analysis of Cullin 7 E3 ubiquitin ligases in cancer
- Le Shi
- , Dongyue Du
- & Jiangang Long
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Article
| Open AccessInhibition of Chk1 by miR-320c increases oxaliplatin responsiveness in triple-negative breast cancer
- Sera Lim
- , Yesol Kim
- & Jong Hoon Park
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Article
| Open AccessEpigenetic activation of the small GTPase TCL contributes to colorectal cancer cell migration and invasion
- Baoyu Chen
- , Zhiwen Fan
- & Yong Xu
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Article
| Open AccessExtracellular signal-regulated kinases associate with and phosphorylate DHPS to promote cell proliferation
- Chao Wang
- , Zhen Chen
- & Junjie Chen
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Article
| Open AccessMethyl-CpG-binding protein 2 drives the Furin/TGF-β1/Smad axis to promote epithelial–mesenchymal transition in pancreatic cancer cells
- Huizhi Wang
- , Jie Li
- & Min Xu
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Article
| Open AccessUSP42 enhances homologous recombination repair by promoting R-loop resolution with a DNA–RNA helicase DHX9
- Misaki Matsui
- , Ryo Sakasai
- & Ryotaro Nishi
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Article
| Open AccessMyotubularin-related protein 7 activates peroxisome proliferator-activated receptor-gamma
- Philip Weidner
- , Michaela Söhn
- & Elke Burgermeister
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Article
| Open AccessMeCP2 facilitates breast cancer growth via promoting ubiquitination-mediated P53 degradation by inhibiting RPL5/RPL11 transcription
- DongDong Tong
- , Jing Zhang
- & Chen Huang
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Article
| Open AccessMiR-93 is related to poor prognosis in pancreatic cancer and promotes tumor progression by targeting microtubule dynamics
- Elena Vila-Navarro
- , Elena Fernandez-Castañer
- & Meritxell Gironella
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Article
| Open AccessCUL4B contributes to cancer stemness by repressing tumor suppressor miR34a in colorectal cancer
- Yanjun Li
- , Huili Hu
- & Yaoqin Gong
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Article
| Open AccessSTAT3 activates MSK1-mediated histone H3 phosphorylation to promote NFAT signaling in gastric carcinogenesis
- Hongyan Qi
- , Zhiyi Yang
- & Jing Shen
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Article
| Open Accessp73 – NAV3 axis plays a critical role in suppression of colon cancer metastasis
- Apoorva Uboveja
- , Yatendra Kumar Satija
- & Daman Saluja
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Article
| Open AccessDNMT3A mutants provide proliferating advantage with augmentation of self-renewal activity in the pathogenesis of AML in KMT2A-PTD-positive leukemic cells
- Rabindranath Bera
- , Ming-Chun Chiu
- & Lee-Yung Shih
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Article
| Open AccessSCFβ-TrCP-mediated degradation of TOP2β promotes cancer cell survival in response to chemotherapeutic drugs targeting topoisomerase II
- Jianfeng Shu
- , Danrui Cui
- & Yongchao Zhao
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Article
| Open AccessDDIAS promotes STAT3 activation by preventing STAT3 recruitment to PTPRM in lung cancer cells
- Joo-Young Im
- , Bo-Kyung Kim
- & Misun Won
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