Mechanotransduction

Mechanotransduction refers to the processes through which cells sense and respond to mechanical stimuli by converting them to biochemical signals that elicit specific cellular responses.

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Latest Research and Reviews

  • Research |

    Moro et al. discover an Argonaute 2 (Ago2)-dependent miRNA network that, in response to substrate stiffness, regulates genes involved in tissue mechanics, and show that Ago2 restrains stiffness and contributes to regeneration in the zebrafish fin fold.

    • Albertomaria Moro
    • , Tristan P. Driscoll
    • , Liana C. Boraas
    • , William Armero
    • , Dionna M. Kasper
    • , Nicolas Baeyens
    • , Charlene Jouy
    • , Venkatesh Mallikarjun
    • , Joe Swift
    • , Sang Joon Ahn
    • , Donghoon Lee
    • , Jing Zhang
    • , Mengting Gu
    • , Mark Gerstein
    • , Martin Schwartz
    •  & Stefania Nicoli
  • Research |

    Romani et al. identify a response to reduced actomyosin contractility involving inhibition of Lipin-1, accumulation of SREBP transcription factors at the Golgi apparatus and activation of SREBP transcription driving increased lipid synthesis.

    • Patrizia Romani
    • , Irene Brian
    • , Giulia Santinon
    • , Arianna Pocaterra
    • , Matteo Audano
    • , Silvia Pedretti
    • , Samuel Mathieu
    • , Mattia Forcato
    • , Silvio Bicciato
    • , Jean-Baptiste Manneville
    • , Nico Mitro
    •  & Sirio Dupont
  • Reviews |

    In this Review, the authors summarize mechanoregulated pathways in cardiac myocytes and fibroblasts that lead to altered gene expression and cell remodelling under physiological and pathophysiological conditions. They also discuss the use of systems modelling to discover new therapies to target mechanosignalling in heart disease.

    • Jeffrey J. Saucerman
    • , Philip M. Tan
    • , Kyle S. Buchholz
    • , Andrew D. McCulloch
    •  & Jeffrey H. Omens
  • Reviews |

    The dynamics of epithelial tissues play a key role in tissue organization, both in health and disease. In this Review, the authors discuss materials and techniques for the study of epithelial movement and mechanics and investigate epithelia as active matter from a theoretical and experimental perspective.

    • Wang Xi
    • , Thuan Beng Saw
    • , Delphine Delacour
    • , Chwee Teck Lim
    •  & Benoit Ladoux

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