Locus coeruleus articles within Nature Communications

Featured

• Article
  09 March 2021 | Open Access

  Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve

  Despite its wide and growing use, the mechanisms by which in vivo vagus nerve stimulation (VNS) exerts its therapeutic benefits are still largely unknown. Here, the authors show in mice that pupil dilation is a reliable and noninvasive biosensor for titratable VNS-evoked cortical neuromodulation by acetylcholine.

  • Zakir Mridha
  • , Jan Willem de Gee
  •  & Matthew James McGinley

• Article
  06 December 2018 | Open Access

  In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness

  Neurons of the locus coeruleus (LC) are implicated in attention and arousal. Here the authors use CRISPR/Cas9 to disrupt dopamine beta hydroxylase in LC neurons and see this reduces LC-evoked sleep-to-wake transitions and wake length.

  • Hiroshi Yamaguchi
  • , F. Woodward Hopf
  •  & Luis de Lecea