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| Open AccessMeta-analysis reveals weak but pervasive plasticity in insect thermal limits
The ability of organisms to acclimate to high temperatures is increasingly put to test by climate change. This global meta-analysis shows that plasticity of thermal limits in insects is widespread but unlikely to keep pace with climate change.
- Hester Weaving
- , John S. Terblanche
- & Sinead English
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Article
| Open AccessOntology-driven weak supervision for clinical entity classification in electronic health records
In the electronic health record, using clinical notes to identify entities such as disorders and their temporality can inform many important analyses. Here, the authors present a framework for weakly supervised entity classification using medical ontologies and expert-generated rules.
- Jason A. Fries
- , Ethan Steinberg
- & Nigam H. Shah
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Article
| Open AccessCapturing variation impact on molecular interactions in the IMEx Consortium mutations data set
Genetic variants might exert their functional effects via influencing molecular interaction. Here, the authors present a resource featuring almost 28,000 annotations describing the effect of small sequence changes on physical protein interactions, curated by IMEx Consortium curators.
- J. Khadake
- , B. Meldal
- & P. Porras