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Lipidomics is the study of the structure and function of the complete set of lipids (the lipidome) produced in a given cell or organism as well as their interactions with other lipids, proteins and metabolites.
Ion-mobility spectrometry (IMS) separates molecules according to charge, shape and size. In this protocol, traveling-wave ion mobility mass spectrometry (TWIMS) is coupled with LC for metabolomics and lipidomics analysis.
Ferroptosis is characterized by accumulation of lipid peroxidation products and lethal ROS, but the source and identity of lipid death signals that cause toxicity are poorly defined. New studies reveal that ACSL4 controls sensitivity to ferroptosis and that oxidized phosphatidylethanolamines are critical for ferroptosis execution.