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Imiquimod exacerbates IL-23-induced skin inflammation and models psoriasis in mice. Here the authors show that this pathology is not dependent on resident dendritic cells, but on CCR6-induced immigration of monocyte-derived cells.
The dendritic cell (DC) network consists of several DC subsets with distinct functions. Here, Gabrielle Belz and Stephen Nutt focus on transcription factors that regulate DC lineage specification in response to developmental and environmental cues.
CD1a on Langerhans cells in the epidermis is the lipid receptor for the plant-derived allergen urushiol and self lipids and is a key amplifier of inflammatory responses in urushiol-induced contact dermatitis as well as in psoriasis.
Paradoxically, radiotherapy can reinforce immunosuppressive pathways that undermine anticancer immunosurveillance and treatment efficacy. Irradiation induces Langerhans cells to migrate from the skin to lymph nodes, where they stimulate regulatory T cells.