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Subversion of anticancer immunosurveillance by radiotherapy

Nature Immunology volume 16, pages 1005–1007 (2015)Cite this article

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Paradoxically, radiotherapy can reinforce immunosuppressive pathways that undermine anticancer immunosurveillance and treatment efficacy. Irradiation induces Langerhans cells to migrate from the skin to lymph nodes, where they stimulate regulatory T cells.

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Figure 1: Immunological effects of radiotherapy.

Marina Corral Spence/Nature Publishing Group

References

  1. Price, J.G. et al. Nat. Immunol. doi:10.1038/ni.3270 (7 September 2015).

  2. Zitvogel, L. & Kroemer, G. Science 349, 476–477 (2015).

    Article  CAS  Google Scholar 

  3. Zitvogel, L. et al. Immunity 39, 74–88 (2013).

    Article  CAS  Google Scholar 

  4. Apetoh, L. et al. Nat. Med. 13, 1050–1059 (2007).

    Article  CAS  Google Scholar 

  5. Obeid, M. et al. Cell Death Differ. 14, 1848–1850 (2007).

    Article  CAS  Google Scholar 

  6. Ko, A. et al. Cell Death Differ. 21, 92–99 (2014).

    Article  CAS  Google Scholar 

  7. Zitvogel, L. et al. Nat. Rev. Immunol. 15, 405 (2015).

    Article  CAS  Google Scholar 

  8. Surace, L. et al. Immunity 42, 767–777 (2015).

    Article  CAS  Google Scholar 

  9. Filatenkov, A. et al. Clin. Cancer Res. doi:10.1158/1078-0432.CCR-14-2824 (13 April 2015).

  10. Deng, L. et al. J. Clin. Invest. 124, 687–695 (2014).

    Article  CAS  Google Scholar 

  11. Xu, J. et al. Cancer Res. 73, 2782–2794 (2013).

    Article  CAS  Google Scholar 

  12. Vatner, R.E. et al. Front Oncol. 4, 325 (2014).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Laurence Zitvogel is with the Gustave Roussy Cancer Campus, Villejuif, France,

    Laurence Zitvogel

  2. Inserm U1015, Villejuif, France, Université Paris Sud-XI, Faculté de Médecine, Le Kremlin Bicêtre, France,

    Laurence Zitvogel

  3. Guido Kroemer is with Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Inserm U1138, Paris, France,

    Guido Kroemer

  4. Université Paris Descartes, Sorbonne Paris Cité, Paris, France,

    Guido Kroemer

  5. Université Pierre et Marie Curie, Paris, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publiques–Hôpitaux de Paris, Paris, France; and Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.,

    Guido Kroemer

  6. the Center of Clinical Investigations in Biotherapies of Cancer 507, Villejuif, France.,

    Laurence Zitvogel

  7. Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publiques–Hôpitaux de Paris, Paris, France,

    Guido Kroemer

  8. Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.,

    Guido Kroemer

Authors
  1. Laurence Zitvogel
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  2. Guido Kroemer
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Correspondence to Laurence Zitvogel.

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Zitvogel, L., Kroemer, G. Subversion of anticancer immunosurveillance by radiotherapy. Nat Immunol 16, 1005–1007 (2015). https://doi.org/10.1038/ni.3236

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