Innate immune cells

Innate immune cells are white blood cells that mediate innate immunity and include basophils, dendritic cells, eosinophils, Langerhans cells, mast cells, monocytes and macrophages, neutrophils and NK cells.

Latest Research and Reviews

  • Reviews |

    Sodium has a crucial role in osmoregulation and fluid balance. In this Review, the authors discuss how sodium is also an important functional modulator of innate and adaptive immune cells and how it might be linked to chronic inflammatory conditions.

    • Nicola Wilck
    • , András Balogh
    • , Lajos Markó
    • , Hendrik Bartolomaeus
    •  & Dominik N. Müller
  • Research |

    IFN-λ has important innate immune system functions at mucosal surfaces, but its importance in adaptive immunity is largely unknown. Using an influenza infection model, Gale and colleagues demonstrate that IFN-λ is essential for effective adaptive cellular immunity in the lung.

    • Emily A. Hemann
    • , Richard Green
    • , J. Bryan Turnbull
    • , Ryan A. Langlois
    • , Ram Savan
    •  & Michael Gale Jr
  • Research | | open

    Composition and function of immune populations at barrier surfaces is crucial for response to infection. Here, the authors identify a population of dendritic cells in human epidermis, abundant in anogenital epithelia and distinct from Langerhans cells by surface phenotype and by high capacity for HIV infection and transmission.

    • Kirstie M. Bertram
    • , Rachel A. Botting
    • , Heeva Baharlou
    • , Jake W. Rhodes
    • , Hafsa Rana
    • , J. Dinny Graham
    • , Ellis Patrick
    • , James Fletcher
    • , Toby M. Plasto
    • , Naomi R. Truong
    • , Caroline Royle
    • , Chloe M. Doyle
    • , Orion Tong
    • , Najla Nasr
    • , Laith Barnouti
    • , Mark P. Kohout
    • , Andrew J. Brooks
    • , Michael P. Wines
    • , Peter Haertsch
    • , Jake Lim
    • , Martijn P. Gosselink
    • , Grahame Ctercteko
    • , Jacob D. Estes
    • , Melissa J. Churchill
    • , Paul U. Cameron
    • , Eric Hunter
    • , Muzlifah A. Haniffa
    • , Anthony L. Cunningham
    •  & Andrew N. Harman
  • Research | | open

    Here, Frisbee et al. show that hypervirulent Clostridium difficile induces IL-33 expression in the gut and IL-33 reduces mortality and morbidity via group 2 innate lymphoid cells. Furthermore, serum levels of the soluble IL-33 decoy receptor, sST2, are associated with enhanced disease severity in human C. difficile patients.

    • Alyse L. Frisbee
    • , Mahmoud M. Saleh
    • , Mary K. Young
    • , Jhansi L. Leslie
    • , Morgan E. Simpson
    • , Mayuresh M. Abhyankar
    • , Carrie A. Cowardin
    • , Jennie Z. Ma
    • , Patcharin Pramoonjago
    • , Stephen D. Turner
    • , Alice P. Liou
    • , Erica L. Buonomo
    •  & William A. Petri Jr.
  • Research |

    Ginhoux and colleagues show that the priming of mouse hematopoietic progenitor cells toward the pDC lineage occurs at the common lymphoid progenitor stage.

    • Regine J. Dress
    • , Charles-Antoine Dutertre
    • , Amir Giladi
    • , Andreas Schlitzer
    • , Ivy Low
    • , Nurhidaya Binte Shadan
    • , Alicia Tay
    • , Josephine Lum
    • , Muhammad Faris Bin Mohd Kairi
    • , You Yi Hwang
    • , Etienne Becht
    • , Yang Cheng
    • , Marion Chevrier
    • , Anis Larbi
    • , Evan W. Newell
    • , Ido Amit
    • , Jinmiao Chen
    •  & Florent Ginhoux
    Nature Immunology 20, 852-864

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