Immunological deficiency syndromes

Immunological deficiency syndromes are diseases or conditions in which there is a loss of or defect in a component of the immune system. Patients with these syndromes have an increased susceptibility to infections and to developing certain cancers. These syndromes include primary immune deficiency diseases, such as severe combined immunodeficiency, and acquired immunodeficiency syndrome (AIDS).

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Latest Research and Reviews

News and Comment

  • News and Views |

    Reassurance provided by pre-exposure prophylaxis (PrEP) for HIV might lead to increased sexual risk-taking in men who have sex with men (MSM), potentially increasing the risk of transmitting other infections. A recent study has shown increased transmission of hepatitis C virus (HCV) in this population, suggesting a need for HCV screening.

    • Douglas S. Krakower
    •  & Kenneth H. Mayer
  • News and Views |

    The zinc transporter ZIP7 positively regulates signaling via the BCR during early B cell development in mice and humans. Impairment of ZIP7 function results in a novel primary immunodeficiency.

    • Toshiyuki Fukada
    • , Shintaro Hojyo
    • , Takafumi Hara
    •  & Teruhisa Takagishi
    Nature Immunology 20, 248-250
  • Comments and Opinion |

    The generation of an HIV vaccine remains the holy grail for eliminating HIV infection worldwide. Major advances in 2018 centred on sequential multi-immunogen strategies that are designed to induce broadly neutralizing antibodies, identifying new targets and defining new approaches to immunogen evaluation.

    • Dennis R. Burton
  • Comments and Opinion |

    Work during the past two decades has highlighted how HIV contributes to hepatic inflammation and fibrosis, leading to changes in the timing of antiretroviral therapy initiation and to improved diagnosis and management of liver disease in patients with HIV. As this population ages, clinician vigilance with early detection of emerging liver disease will be critical.

    • Naichaya Chamroonkul
    •  & Meena B. Bansal