Lymphopaenia

Definition

Lymphopaenia is an abnormal reduction in lymphocyte numbers. Causes of lymphopaenia include infection, disease, chemotherapy and radiotherapy.

Latest Research and Reviews

  • Research |

    Erwin Gelfand, Andrew Snow, Joshua Milner and colleagues identify heterozygous CARD11 mutations associated with severe atopic disease in eight individuals from four families. They further show that the mutant CARD11 proteins exhibit both loss-of-function and dominant-interfering activity and that the cellular defects in patient T cells can be partially rescued by supplementing with glutamine.

    • Chi A Ma
    • , Jeffrey R Stinson
    • , Yuan Zhang
    • , Jordan K Abbott
    • , Michael A Weinreich
    • , Pia J Hauk
    • , Paul R Reynolds
    • , Jonathan J Lyons
    • , Celeste G Nelson
    • , Elisa Ruffo
    • , Batsukh Dorjbal
    • , Salomé Glauzy
    • , Natsuko Yamakawa
    • , Swadhinya Arjunaraja
    • , Kelsey Voss
    • , Jennifer Stoddard
    • , Julie Niemela
    • , Yu Zhang
    • , Sergio D Rosenzweig
    • , Joshua J McElwee
    • , Thomas DiMaggio
    • , Helen F Matthews
    • , Nina Jones
    • , Kelly D Stone
    • , Alejandro Palma
    • , Matías Oleastro
    • , Emma Prieto
    • , Andrea R Bernasconi
    • , Geronimo Dubra
    • , Silvia Danielian
    • , Jonathan Zaiat
    • , Marcelo A Marti
    • , Brian Kim
    • , Megan A Cooper
    • , Neil Romberg
    • , Eric Meffre
    • , Erwin W Gelfand
    • , Andrew L Snow
    •  & Joshua D Milner
    Nature Genetics 49, 1192–1201
  • Research |

    Boztug and colleagues identify an immunodeficient patient with a deficiency in the guanine-nucleotide-exchange factor RASGRP1. They find that human RASGRP1 is important for the function of T cells, B cells and NK cells and that it has a role in the regulation of the cytoskeleton.

    • Elisabeth Salzer
    • , Deniz Cagdas
    • , Miroslav Hons
    • , Emily M Mace
    • , Wojciech Garncarz
    • , Özlem Yüce Petronczki
    • , René Platzer
    • , Laurène Pfajfer
    • , Ivan Bilic
    • , Sol A Ban
    • , Katharina L Willmann
    • , Malini Mukherjee
    • , Verena Supper
    • , Hsiang Ting Hsu
    • , Pinaki P Banerjee
    • , Papiya Sinha
    • , Fabienne McClanahan
    • , Gerhard J Zlabinger
    • , Winfried F Pickl
    • , John G Gribben
    • , Hannes Stockinger
    • , Keiryn L Bennett
    • , Johannes B Huppa
    • , Loïc Dupré
    • , Özden Sanal
    • , Ulrich Jäger
    • , Michael Sixt
    • , Ilhan Tezcan
    • , Jordan S Orange
    •  & Kaan Boztug
    Nature Immunology 17, 1352–1360
  • Reviews |

    Interleukin-7 (IL-7) induces T cell proliferation and enhances antigen-specific immune responses: attributes that pinpoint its value as a potential therapeutic agent. This Review summarizes preclinical and clinical data on the immunorestorative effects of IL-7 in various pathologies and discusses the conditions for which IL-7 therapy might be of use.

    • Crystal L. Mackall
    • , Terry J. Fry
    •  & Ronald E. Gress

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