HIV infections articles within Nature Chemistry

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• News & Views | 23 August 2012

  Forcing an enemy into the open

  A series of highly active, simplified analogues of the natural product bryostatin have been prepared. They offer an improved approach for the activation of latent HIV that could, in combination with current state-of-the-art antiretroviral therapy, offer hope for eventual eradication of the infection.

  • Christian Melander
  •  & David M. Margolis

• Article | 15 July 2012

  Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro

  Simplified bryostatin analogues are shown to potently induce latent HIV expression in vitro. These analogues display comparable or better potency when compared with bryostatin. Moreover, they are up to 1,000-fold more potent in inducing latent HIV expression than prostratin, the current lead preclinical candidate.

  • Brian A. DeChristopher
  • , Brian A. Loy
  •  & Paul A. Wender