A series of highly active, simplified analogues of the natural product bryostatin have been prepared. They offer an improved approach for the activation of latent HIV that could, in combination with current state-of-the-art antiretroviral therapy, offer hope for eventual eradication of the infection.
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Melander, C., Margolis, D. Forcing an enemy into the open. Nature Chem 4, 692–693 (2012). https://doi.org/10.1038/nchem.1444
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DOI: https://doi.org/10.1038/nchem.1444
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Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists
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