Hepatitis articles within Nature Reviews Nephrology

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  • Review Article |

    This Review describes the epidemiology and mechanisms underlying the reciprocal relationship between hepatitis C virus (HCV) infection and chronic kidney disease (CKD). The authors also discuss recommended treatment approaches for patients with HCV infection and CKD, and outline remaining issues in the field.

    • Stanislas Pol
    • , Lucia Parlati
    •  & Michel Jadoul

  • Review Article |

    Hepatitis C virus (HCV) infection imposes a substantial economic, clinical, and societal burden worldwide. In this Review, Morales and Fabrizi compare the treatment options that are available to patients with HCV infection, before and after renal transplantation. The development of novel therapeutic strategies and the clinical complications associated with HCV infection are discussed. The authors conclude with an assessment of the safe use of organs donated from individuals with active HCV infection.

    • Jose M. Morales
    •  & Fabrizio Fabrizi

  • Review Article |

    Infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) in kidney transplant candidates was once considered a contraindication to transplantation, but advances in antiviral therapy have now enabled successful transplantation in these patients. In this Review, Huskey and Wiseman discuss the management of chronic HBV and HCV infection in both kidney donors and recipients, including post-transplantation outcomes and recommendations for treatment and organ allocation in these individuals.

    • Janna Huskey
    •  & Alexander C. Wiseman

  • Review Article |

    Liver disease can negatively affect clinical outcomes of patients with chronic kidney disease and patients who have undergone renal transplantation. Hepatitis B virus and hepatitis C virus infections are the most common form of liver disease in such patients. In this article, Fabrizi and colleagues discuss the natural history, clinical course, diagnosis and management of liver disorders associated with hepatitis B virus and hepatitis C virus infection in patients with chronic kidney disease and in renal transplant recipients, and also briefly describe other causes of liver disease in such patients.

    • Fabrizio Fabrizi
    • , Piergiorgio Messa
    •  & Paul Martin

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