Glomerular diseases articles within Nature Reviews Endocrinology

Featured

  • News & Views |

    Lysosomal acid lipase deficiency can lead to liver failure and early death. A recently published placebo-controlled trial shows that enzyme-replacement therapy improves plasma levels of lipids and aminotransferases, and reduces liver fat content. However, the effect on clinical end points and an appropriate indication for treatment remain to be established.

    • Carla E. M. Hollak
    •  & G. Kees Hovingh

  • News & Views |

    In a prospective study of patients with type 1 diabetes mellitus, leisure time physical activity of low intensity at baseline (versus high intensity) was associated with the development and progression of nephropathy. This finding is consistent with previous reports that exercise delays the progression of chronic kidney disease in people with or without diabetes mellitus.

    • George Jerums
    •  & Richard J. MacIsaac

  • Review Article |

    This Review summarizes the role of reactive oxygen species and oxidative stress in diabetes mellitus and in the pathogenesis of endothelial cell dysfunction and diabetic nephropathy. Furthermore, the authors explore possible therapeutic interventions to reduce oxidative stress and endothelial cell dysfunction and retard the progression of diabetic nephropathy.

    • Dhruv K. Singh
    • , Peter Winocour
    •  & Ken Farrington

  • News & Views |

    Combination therapy with vitamins B6, B9 and B12 is a therapeutic intervention to decrease levels of plasma homocysteine and the risk of cardiovascular disease. However, a recent trial found that cosupplementation with these vitamins exacerbated the decline in renal function and increased the risk of vascular disease in patients with diabetic nephropathy. Confidence in this high-dose vitamin supplement is shaken.

    • Paul J. Thornalley
    •  & Naila Rabbani

Browse broader subjects

Browse narrower subjects

Browse Glomerular diseases across other nature.com journals