Germ cell tumours

Definition

Germ cell tumours form from reproductive cells and can be cancerous or noncancerous. When cancerous, they normally develop as cancer of the testicles in men or of the ovaries in women. Germ cell tumours can be given different names according to their characteristics; for example, yolk-sac tumours, germinomas, embryonal carcinomas, teratomas and immature teratomas.

Latest Research and Reviews

  • Research |

    Clare Turnbull and colleagues report discovery of 19 new susceptibility loci for testicular germ cell tumor (TGCT) and provide evidence for a network of physical interactions between TGCT risk variants and candidate causal genes. Their findings implicate widespread disruption of developmental transcriptional regulators in TGCT susceptibility, consistent with failed primordial germ cell differentiation as an initiating step in oncogenesis.

    • Kevin Litchfield
    • , Max Levy
    • , Giulia Orlando
    • , Chey Loveday
    • , Philip J Law
    • , Gabriele Migliorini
    • , Amy Holroyd
    • , Peter Broderick
    • , Robert Karlsson
    • , Trine B Haugen
    • , Wenche Kristiansen
    • , Jérémie Nsengimana
    • , Kerry Fenwick
    • , Ioannis Assiotis
    • , ZSofia Kote-Jarai
    • , Alison M Dunning
    • , Kenneth Muir
    • , Julian Peto
    • , Rosalind Eeles
    • , Douglas F Easton
    • , Darshna Dudakia
    • , Nick Orr
    • , Nora Pashayan
    • , UK Testicular Cancer Collaboration
    • , The PRACTICAL Consortium
    • , D Timothy Bishop
    • , Alison Reid
    • , Robert A Huddart
    • , Janet Shipley
    • , Tom Grotmol
    • , Fredrik Wiklund
    • , Richard S Houlston
    •  & Clare Turnbull
  • Research |

    Genomic analyses show that primary germ-cell tumours are highly enriched for chromosomal reciprocal loss of heterozygosity, mutations in KRAS and have high mitochondrial priming, providing insight into chemosensitivity and the evolution of chemoresistance in this disease.

    • Amaro Taylor-Weiner
    • , Travis Zack
    • , Elizabeth O’Donnell
    • , Jennifer L. Guerriero
    • , Brandon Bernard
    • , Anita Reddy
    • , G. Celine Han
    • , Saud AlDubayan
    • , Ali Amin-Mansour
    • , Steven E. Schumacher
    • , Kevin Litchfield
    • , Clare Turnbull
    • , Stacey Gabriel
    • , Rameen Beroukhim
    • , Gad Getz
    • , Scott L. Carter
    • , Michelle S. Hirsch
    • , Anthony Letai
    • , Christopher Sweeney
    •  & Eliezer M Van Allen
    Nature 540, 114–118
  • Reviews |

    Ovarian cancer comprises a broad range of histologically and genetically different tumours. In this Opinion article, Karnezis et al. explore the different origins of ovarian cancers and how these contribute to our understanding of genetic and environmental risk to better prevent and treat these tumours.

    • Anthony N. Karnezis
    • , Kathleen R. Cho
    • , C. Blake Gilks
    • , Celeste Leigh Pearce
    •  & David G. Huntsman
  • Research | | open

    There is some evidence of a hereditary risk for developing testicular germ cell tumours. Here, the authors use whole-exome sequencing and identify a risk variant for the disease in DNAAF1, a gene involved in microtubule-based cilia.

    • Kevin Litchfield
    • , Max Levy
    • , Darshna Dudakia
    • , Paula Proszek
    • , Claire Shipley
    • , Sander Basten
    • , Elizabeth Rapley
    • , D. Timothy Bishop
    • , Alison Reid
    • , Robert Huddart
    • , Peter Broderick
    • , David Gonzalez de Castro
    • , Simon O'Connor
    • , Rachel H. Giles
    • , Richard S. Houlston
    •  & Clare Turnbull

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