Genome informatics

Definition

Genome informatics is the field in which computer and statistical techniques are applied to derive biological information from genome sequences. Genome informatics includes methods to analyse DNA sequence information and to predict protein sequence and structure.

Latest Research and Reviews

  • Research | | open

    Biomphalaria glabrata is a fresh water snail that acts as a host for trematode Schistosoma mansoni that causes intestinal infection in human. This work describes the genome and transcriptome analyses from 12 different tissues of B glabrata, and identify genes for snail behavior and evolution.

    • Coen M. Adema
    • , LaDeana W. Hillier
    • , Catherine S. Jones
    • , Eric S. Loker
    • , Matty Knight
    • , Patrick Minx
    • , Guilherme Oliveira
    • , Nithya Raghavan
    • , Andrew Shedlock
    • , Laurence Rodrigues do Amaral
    • , Halime D. Arican-Goktas
    • , Juliana G. Assis
    • , Elio Hideo Baba
    • , Olga L. Baron
    • , Christopher J. Bayne
    • , Utibe Bickham-Wright
    • , Kyle K. Biggar
    • , Michael Blouin
    • , Bryony C. Bonning
    • , Chris Botka
    • , Joanna M. Bridger
    • , Katherine M. Buckley
    • , Sarah K. Buddenborg
    • , Roberta Lima Caldeira
    • , Julia Carleton
    • , Omar S. Carvalho
    • , Maria G. Castillo
    • , Iain W. Chalmers
    • , Mikkel Christensens
    • , Sandra Clifton
    • , Celine Cosseau
    • , Christine Coustau
    • , Richard M. Cripps
    • , Yesid Cuesta-Astroz
    • , Scott F. Cummins
    • , Leon di Stephano
    • , Nathalie Dinguirard
    • , David Duval
    • , Scott Emrich
    • , Cédric Feschotte
    • , Rene Feyereisen
    • , Peter FitzGerald
    • , Catrina Fronick
    • , Lucinda Fulton
    • , Richard Galinier
    • , Sandra G. Gava
    • , Michael Geusz
    • , Kathrin K. Geyer
    • , Gloria I. Giraldo-Calderón
    • , Matheus de Souza Gomes
    • , Michelle A. Gordy
    • , Benjamin Gourbal
    • , Christoph Grunau
    • , Patrick C. Hanington
    • , Karl F. Hoffmann
    • , Daniel Hughes
    • , Judith Humphries
    • , Daniel J. Jackson
    • , Liana K. Jannotti-Passos
    • , Wander de Jesus Jeremias
    • , Susan Jobling
    • , Bishoy Kamel
    • , Aurélie Kapusta
    • , Satwant Kaur
    • , Joris M. Koene
    • , Andrea B. Kohn
    • , Dan Lawson
    • , Scott P Lawton
    • , Di Liang
    • , Yanin Limpanont
    • , Sijun Liu
    • , Anne E. Lockyer
    • , TyAnna L. Lovato
    • , Fernanda Ludolf
    • , Vince Magrini
    • , Donald P. McManus
    • , Monica Medina
    • , Milind Misra
    • , Guillaume Mitta
    • , Gerald M. Mkoji
    • , Michael J. Montague
    • , Cesar Montelongo
    • , Leonid L. Moroz
    • , Monica C. Munoz-Torres
    • , Umar Niazi
    • , Leslie R. Noble
    • , Francislon S. Oliveira
    • , Fabiano S. Pais
    • , Anthony T. Papenfuss
    • , Rob Peace
    • , Janeth J. Pena
    • , Emmanuel A. Pila
    • , Titouan Quelais
    • , Brian J. Raney
    • , Jonathan P. Rast
    • , David Rollinson
    • , Izinara C. Rosse
    • , Bronwyn Rotgans
    • , Edwin J. Routledge
    • , Kathryn M. Ryan
    • , Larissa L. S. Scholte
    • , Richard K. Wilson
    • , Kenneth B. Storey
    • , Si-Ming Zhang
    • , Min Zhao
    • , Chad Tomlinson
    • , Mohammed Yusuf
    • , Jacob A. Tennessen
    • , Anthony J. Walker
    • , Timothy P. Yoshino
    • , Emanuela V. Volpi
    • , Damian L. Trujillo
    • , Xiao-Jun Wu
    • , Martin Swain
    • , Tianfang Wang
    • , Ittiprasert Wannaporn
    •  & Wesley C. Warren

News and Comment

  • News |

    PCR duplicates—sequencing reads from the same original genomic fragment—can cause headaches. But there are remedies.

    • Vivien Marx
    Nature Methods 14, 473–476
  • News and Views |

    The newly described de novo goat genome sequence is the most contiguous diploid vertebrate assembly generated thus far using whole-genome assembly and scaffolding methods. The contiguity of this assembly is approaching that of the finished human and mouse genomes and suggests an affordable roadmap to high-quality references for thousands of species.

    • Kim C Worley
    Nature Genetics 49, 485–486
  • Editorial |

    Investment in national infrastructure should include a scalable open informatics solution for agricultural genomics, germplasm and crop traits. This is a priority measure for economic stimulus and food security. As building this knowledge harvester should be simpler than the infrastructure required for precision medicine, it will also pave the way to that goal.