Genome assembly algorithms

Definition

Genome assembly algorithms are sets of well defined procedures for reconstructing DNA sequences from large numbers of shorter DNA sequence fragments. Fragments are aligned against one another and overlapping sections are identified and merged.

Latest Research and Reviews

  • Research | | open

    High-quality reference genomes facilitate analysis of genome structure and variation. Here Du et al. create a near-complete assembly of the indica rice genome by combining single molecule sequencing with mapping data and fosmid sequences and identify genetic variants by comparison with other rice genomes.

    • Huilong Du
    • , Ying Yu
    • , Yanfei Ma
    • , Qiang Gao
    • , Yinghao Cao
    • , Zhuo Chen
    • , Bin Ma
    • , Ming Qi
    • , Yan Li
    • , Xianfeng Zhao
    • , Jing Wang
    • , Kunfan Liu
    • , Peng Qin
    • , Xin Yang
    • , Lihuang Zhu
    • , Shigui Li
    •  & Chengzhi Liang
  • Research | | open

    • Sebastian Beier
    • , Axel Himmelbach
    • , Christian Colmsee
    • , Xiao-Qi Zhang
    • , Roberto A. Barrero
    • , Qisen Zhang
    • , Lin Li
    • , Micha Bayer
    • , Daniel Bolser
    • , Stefan Taudien
    • , Marco Groth
    • , Marius Felder
    • , Alex Hastie
    • , Hana Šimková
    • , Helena Staňková
    • , Jan Vrána
    • , Saki Chan
    • , María Muñoz-Amatriaín
    • , Rachid Ounit
    • , Steve Wanamaker
    • , Thomas Schmutzer
    • , Lala Aliyeva-Schnorr
    • , Stefano Grasso
    • , Jaakko Tanskanen
    • , Dharanya Sampath
    • , Darren Heavens
    • , Sujie Cao
    • , Brett Chapman
    • , Fei Dai
    • , Yong Han
    • , Hua Li
    • , Xuan Li
    • , Chongyun Lin
    • , John K. McCooke
    • , Cong Tan
    • , Songbo Wang
    • , Shuya Yin
    • , Gaofeng Zhou
    • , Jesse A. Poland
    • , Matthew I. Bellgard
    • , Andreas Houben
    • , Jaroslav Doležel
    • , Sarah Ayling
    • , Stefano Lonardi
    • , Peter Langridge
    • , Gary J. Muehlbauer
    • , Paul Kersey
    • , Matthew D. Clark
    • , Mario Caccamo
    • , Alan H. Schulman
    • , Matthias Platzer
    • , Timothy J. Close
    • , Mats Hansson
    • , Guoping Zhang
    • , Ilka Braumann
    • , Chengdao Li
    • , Robbie Waugh
    • , Uwe Scholz
    • , Nils Stein
    •  & Martin Mascher
    Scientific Data 4, 170044
  • Research | | open

    Jia-Xing Yue, Gianni Liti and colleagues use long-read sequencing to generate complete genome assemblies of 7 Saccharomyces cerevisiae and 5 Saccharomyces paradoxus strains. They use these data to define boundaries between chromosomal core and subtelomeric regions and to compare the evolutionary dynamics between these domesticated and wild yeast species.

    • Jia-Xing Yue
    • , Jing Li
    • , Louise Aigrain
    • , Johan Hallin
    • , Karl Persson
    • , Karen Oliver
    • , Anders Bergström
    • , Paul Coupland
    • , Jonas Warringer
    • , Marco Cosentino Lagomarsino
    • , Gilles Fischer
    • , Richard Durbin
    •  & Gianni Liti
  • Research | | open

    Genome assembly for many plant species can be challenging due to large size and high repeat content. Here, the authors use in vitro proximity ligation to assemble the genome of lettuce, revealing a family-specific triplication event and providing a comprehensive reference genome for a member of the Compositae.

    • Sebastian Reyes-Chin-Wo
    • , Zhiwen Wang
    • , Xinhua Yang
    • , Alexander Kozik
    • , Siwaret Arikit
    • , Chi Song
    • , Liangfeng Xia
    • , Lutz Froenicke
    • , Dean O. Lavelle
    • , María-José Truco
    • , Rui Xia
    • , Shilin Zhu
    • , Chunyan Xu
    • , Huaqin Xu
    • , Xun Xu
    • , Kyle Cox
    • , Ian Korf
    • , Blake C. Meyers
    •  & Richard W. Michelmore

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