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News & Views |
Ancient DNA uncovers past migrations in California
Genomic data from ancient humans who lived up to 7,400 years ago, sampled from across California and Mexico, unveil patterns of migration that could explain how some Indigenous languages spread in parts of North America.
- Alan Izarraras-Gomez
- & Diego Ortega-Del Vecchyo
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Article |
Phages overcome bacterial immunity via diverse anti-defence proteins
A study reports the discovery and characterization of four distinct families of phage-encoded anti-defence proteins that inhibit a variety of bacterial defence systems.
- Erez Yirmiya
- , Azita Leavitt
- & Rotem Sorek
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Article |
Genetic continuity and change among the Indigenous peoples of California
Genome-wide analyses of ancient DNA from individuals from California and Mexico shed light on the spread of Mexican ancestry to California and how it correlates with linguistic flow.
- Nathan Nakatsuka
- , Brian Holguin
- & David Reich
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News |
Massive genetic study finds genes linked to cannabis addiction
Data from more than one million genomes offer fresh insights into excessive cannabis use and its relationship to other diseases.
- Lilly Tozer
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News |
UK first to approve CRISPR treatment for diseases: what you need to know
The landmark decision could transform the treatment of sickle-cell disease and β-thalassaemia — but the technology is expensive.
- Carissa Wong
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Article
| Open AccessEmbryo-scale reverse genetics at single-cell resolution
We present the ‘zebrafish single-cell atlas of perturbed embryos’, single-cell trancriptomic data of developing zebrafish embryos across various timepoints and with genetic perturbations.
- Lauren M. Saunders
- , Sanjay R. Srivatsan
- & Cole Trapnell
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Article
| Open AccessSingle-cell, whole-embryo phenotyping of mammalian developmental disorders
A study reports single-cell RNA-sequencing profiles for more than 1.6 million cell nuclei from 101 whole mouse embryos including 22 mutant and 4 wild-type genotypes, from one experiment.
- Xingfan Huang
- , Jana Henck
- & Malte Spielmann
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News |
First trial of ‘base editing’ in humans lowers cholesterol — but raises safety concerns
Super-precise gene-editing approach switches off a gene in the liver that regulates ‘bad’ cholesterol.
- Miryam Naddaf
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News |
AI that reads brain scans shows promise for finding Alzheimer’s genes
Machine-learning approach detects Alzheimer’s disease with an accuracy of more than 90% — a potential boon for clinicians and scientists developing treatments.
- Max Kozlov
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News |
Engineered yeast breaks new record: a genome with over 50% synthetic DNA
Highly edited strain survives and replicates despite containing 7.5 artificial chromosomes.
- Katherine Bourzac
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Perspective |
Functional genomics and systems biology in human neuroscience
Technical developments and large collaborative research networks in neurogenomics promise rapid progress in neuroscience, but translation of results from model systems to human brains is limited by sample availability, technical challenges and ethical issues.
- Genevieve Konopka
- & Aparna Bhaduri
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Article |
Latent human herpesvirus 6 is reactivated in CAR T cells
Genomics analyses reveal that in vitro culture of CAR T cells can lead to reactivation of a latent herpesvirus, which might be involved in complications in patients receiving associated cell therapies.
- Caleb A. Lareau
- , Yajie Yin
- & Ansuman T. Satpathy
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Article |
TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
Trinucleotide-repeat-containing 18 (TNRC18), which has poorly understood functions, is now identified as an H3K9me3-specific reader that silences endogenous retroviruses.
- Shuai Zhao
- , Jiuwei Lu
- & Gang Greg Wang
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Article
| Open AccessAutoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency
Inborn errors of the alternative NF-κB pathway in humans impair the development of AIRE-expressing medullary thymic epithelial cells, thereby underlying the production of autoantibodies against type I IFNs and predisposition to viral diseases
- Tom Le Voyer
- , Audrey V. Parent
- & Anne Puel
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Where I Work |
How to make petunias naturally orange
Biotechnologist Sara Abdou explores the genetics that regulate colour in ornamental flowers.
- Nikki Forrester
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News |
How to keep wildcats wild: ancient DNA offers fresh insights
Ancient-genomics studies are boosting efforts to save Scotland’s endangered ‘Highland tigers’ — and keep them separate from domestic cats.
- Ewen Callaway
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Research Highlight |
Woolly-rhino genome emerges from cave hyena’s fossilized poo
Analysis shows that the now-extinct beast split into two populations almost half a million years ago.
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Nature Video |
How would a starfish wear trousers? Science has an answer
Gene expression reveals the story behind starfishes’ strange five-armed body plans
- Shamini Bundell
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Research Briefing |
Genome rewriting generates mouse models of human diseases
Many human diseases lack accurate mouse models because it is technically difficult to create extensively genetically humanized mice. A technique that allows large stretches of DNA to be rapidly rewritten in mouse embryonic stem cells can be used to produce improved animal models.
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Nature Podcast |
A new hydrogel can be directly injected into muscle to help it regenerate
A soft and conductive material shows promise for muscle rehabilitation, and why starfishes have such strange body plans.
- Nick Petrić Howe
- & Shamini Bundell
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Article |
Condensin dysfunction is a reproductive isolating barrier in mice
Species divergence in condensin regulation and centromere organization between the mice Mus musculus domesticus and Mus spretus drives chromosome decondensation and mis-segregation in their F1 hybrid oocytes, reducing female fertility.
- Warif El Yakoubi
- & Takashi Akera
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Article
| Open AccessMouse genome rewriting and tailoring of three important disease loci
This study describes a method to insert large stretches of exogenous DNA into mammalian genomes, which is used to insert human ACE2 loci into mouse to produce a model of human SARS-CoV-2 infection.
- Weimin Zhang
- , Ilona Golynker
- & Jef D. Boeke
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News Explainer |
Is CRISPR safe? Genome editing gets its first FDA scrutiny
Advisers to the US regulatory agency will examine the safety profile of a CRISPR-based treatment for sickle-cell disease.
- Heidi Ledford
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News & Views |
Anti-COVID drug accelerates viral evolution
Molnupiravir, an antiviral drug used to treat COVID-19, induces numerous mutations in the SARS-CoV-2 genome that can increase the rate at which the virus evolves — yielding viral variants that might survive and be passed on.
- Sergei L. Kosakovsky Pond
- & Darren Martin
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Research Highlight |
Ancient DNA reveals traces of elusive first humans in Europe
Europe’s earliest Homo sapiens seemed to have vanished without a genetic legacy — but genomic studies now show otherwise.
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News |
Mysterious mouse mummies found atop lofty volcanoes
Naturally freeze-dried leaf-eared mice found above 6,000 metres show mammals can dwell at extraordinary heights.
- Anil Oza
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Editorial |
How to share data — not just equally, but equitably
Just as with many natural resources, wealthy countries have been extracting scientific data from poorer nations for centuries. Researchers are changing that.
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News Feature |
Apple revival: how science is bringing historic varieties back to life
Exploring the genomes of half-forgotten and heirloom apple varieties could help to ensure the future of the incomparable fruits.
- Christopher Kemp
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Career Column |
Methods section too short? Use online protocols to make complex techniques understandable
New wet-lab methods can be hard to share owing to their complexity, but with a little extra effort, you can give users a leg-up in getting started.
- Lars Borm
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News |
This is the largest map of the human brain ever made
Researchers catalogue more than 3,000 different types of cell in our most complex organ.
- Gemma Conroy
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Article
| Open AccessGenotyping, sequencing and analysis of 140,000 adults from Mexico City
Genotype and exome sequencing of 150,000 participants and whole-genome sequencing of 9,950 selected individuals recruited into the Mexico City Prospective Study constitute a valuable, publicly available resource of non-European sequencing data.
- Andrey Ziyatdinov
- , Jason Torres
- & Roberto Tapia-Conyer
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Article
| Open AccessMexican Biobank advances population and medical genomics of diverse ancestries
Nationwide genomic biobank in Mexico unravels demographic history and complex trait architecture from 6,057 individuals.
- Mashaal Sohail
- , María J. Palma-Martínez
- & Andrés Moreno-Estrada
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Nature Podcast |
Gene edits move pig organs closer to human transplantation
Monkeys with CRISPR-edited pig kidneys survive for more than a year, and why our brains struggle to count more than four objects.
- Benjamin Thompson
- & Shamini Bundell
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Obituary |
M. S. Swaminathan (1925–2023), leader of India’s ‘green revolution’
Agricultural scientist who introduced crops to end famine in India in the 1960s.
- Gayathri Vaidyanathan
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News |
Gene therapies for rare diseases are under threat. Scientists hope to save them
As industry steps aside, scientists seek innovative ways to make sure expensive treatments can reach people who need them.
- Heidi Ledford
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Research Highlight |
How carrots became orange: genomics get at the root of the matter
The vegetable was domesticated roughly 1,200 years ago but was yellow or purple for centuries.
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Career Column |
Embracing the command line: my unexpected career in computational biology
A crash course in bioinformatics put Ming Tommy Tang on a different path.
- Ming Tommy Tang
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Article
| Open AccessRare variant associations with plasma protein levels in the UK Biobank
A set of three papers in Nature reports a new proteomics resource from the UK Biobank and initial analysis of common and rare genetic variant associations with plasma protein levels.
- Ryan S. Dhindsa
- , Oliver S. Burren
- & Slavé Petrovski
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Article
| Open AccessLarge-scale plasma proteomics comparisons through genetics and disease associations
Comparisons of phenotypic and genetic association with protein levels from Icelandic and UK Biobank cohorts show that using multiple analysis platforms and stratifying populations by ancestry improves the detection of associations and allows the refinement of their location within the genome.
- Grimur Hjorleifsson Eldjarn
- , Egil Ferkingstad
- & Kari Stefansson
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Article
| Open AccessPlasma proteomic associations with genetics and health in the UK Biobank
The Pharma Proteomics Project generates the largest open-access plasma proteomics dataset to date, offering insights into trans protein quantitative trait loci across multiple biological domains, and highlighting genetic influences on ligand–receptor interactions and pathway perturbations across a diverse collection of cytokines and complement networks.
- Benjamin B. Sun
- , Joshua Chiou
- & Christopher D. Whelan
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Perspective |
The status of the human gene catalogue
Although the catalogue of human protein-coding genes is nearing completion, the number of non-coding RNA genes remains highly uncertain, and for all genes much work remains to be done to understand their functions.
- Paulo Amaral
- , Silvia Carbonell-Sala
- & Steven L. Salzberg
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Career Guide |
How to spice up your bioinformatics skill set with AI
Incorporating machine-learning tools into data analysis can accelerate discovery and free up valuable time.
- Rachael Pells
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Nature Podcast |
Astronomers are worried by a satellite brighter than most stars
Researchers determined the telecommunications satellite was periodically brighter than 99% of stars, and powerful X-rays have uncovered an ancient trilobite’s last meal.
- Benjamin Thompson
- & Nick Petrić Howe
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News & Views |
Master regulator of a mosquito X chromosome discovered
In organisms with X and Y chromosomes, gene expression must be equalized between the sexes. A protein that causes upregulation of gene expression of the X chromosome in male mosquitoes has been discovered.
- Maggie P. Lauria Sneideman
- & Victoria H. Meller
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Article
| Open AccessThe sex-specific factor SOA controls dosage compensation in Anopheles mosquitoes
A newly identified gene, sex chromosome activation (SOA), is a master regulator of dosage compensation in Anopheles gambiae.
- Agata Izabela Kalita
- , Eric Marois
- & Claudia Isabelle Keller Valsecchi
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Nature Video |
The very first beat: how a heart starts to pulse
Hours of footage of zebrafish embryos let researchers capture and study this key moment in development.
- Shamini Bundell
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Article |
Transposon-encoded nucleases use guide RNAs to promote their selfish spread
TnpB and IscB nucleases use transposon-encoded guide RNAs to target genomic sequences for cleavage, thereby favouring copying and spreading of transposable elements.
- Chance Meers
- , Hoang C. Le
- & Samuel H. Sternberg
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Article
| Open AccesspiRNA processing by a trimeric Schlafen-domain nuclease
The endoribonuclease PUCH, a trimer of Schlafen-like-domain proteins, initiates piRNA processing in the nematode Caenorhabditis elegans through 5′-end piRNA precursor cleavage.
- Nadezda Podvalnaya
- , Alfred W. Bronkhorst
- & René F. Ketting
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