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Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases
The structural diversity of natural products offers great potential for the identification of new drugs. Here, the gene cluster responsible for the production of a meroterpenoid, pyripyropene, has been identified, and reconstitution of the biosynthetic sequence involved allows the production of analogous synthetic structures with potentially new bioactivity.
- Takayuki Itoh
- , Kinya Tokunaga
- & Tetsuo Kushiro